DataVXAdvanced Optical MaterialsPaper
journal article·2025-12Open access

Near‐Infrared Lifetime Nanothermometry Detects Microwave‐Induced Brain Heating

Liyan Ming, José Lifante, Ginés Lifante Pedrola, Daniel Ortega, Irene Zabala‐Gutierrez, Jorge Rubio‐Retama, Erving Ximendes, Riccardo Marin, Julio Ramiro Bargueño, Daniel Jaque

Advanced Optical Materials· Volume 13· Issue 36
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Source abstract

Abstract

Abstract In modern environments, the brain is continuously exposed to numerous external stimuli, including the microwave radiation used in telecommunication technologies. It has been suggested that the absorption of this radiation by brain tissue can induce local heating. Because brain temperature influences neural activity, metabolism, and overall brain function, microwave‐induced heating raises concerns over the safety of such technologies. Proper evaluation of the risks associated with microwave‐based technologies thus requires accurate quantification of heating in deep organs without disrupting their physiology. This study, demonstrates that microwave‐induced brain heating can be remotely monitored in vivo via luminescence thermometry using near‐infrared luminescent silver sulfide (Ag 2 S) nanoparticles. Their temperature‐dependent luminescence lifetime is a reliable thermometric parameter for the measurement of absolute brain temperature. The in vivo results offer direct, real‐time evidence of brain heating (up to 4 °C) under telecom exposure conditions (3 GHz). Moreover, they establish lifetime thermometry as a reliable, minimally invasive approach for investigating thermoregulation in deep tissues even under external electromagnetic stimulation.
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Research context

Nanomaterials

OpenAlex topics: Electromagnetic Fields and Biological Effects · Ultrasound and Hyperthermia Applications · Thermal Radiation and Cooling Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Nanomaterials for Bioimaging Group (nanoBIG) Departamento de Física de Materiales Facultad de Ciencias Universidad Autónoma de Madrid Madrid 28049 Spain

Nanomaterials for Bioimaging Group (nanoBIG) Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) Hospital Ramón y Cajal Madrid 28034 Spain

Instituto de Ciencia de Materiales Nicolás Cabrera Universidad Autónoma de Madrid Madrid 28049 Spain

Neuroimmunology Lab, Department of Neurology and Neurosurgery, The Montreal Neurological Institute (MNI) McGill University 3801 University Road Montreal QC H3A 2B4 Canada

Condensed Matter Physics department, Faculty of Sciences Campus Universitario de Puerto Real Puerto Real Cádiz 11510 Spain

INiBICA ‐ Instituto de Investigación e Innovación Biomédica de Cádiz Biomedical Research and Innovation Institute of Cádiz Cádiz 11009 Spain

IMDEA Nanoscience Faraday 9 Madrid 28049 Spain

Department of Chemistry in Pharmaceutical Sciences, Pharmacy Faculty Complutense University of Madrid Madrid 28040 Spain

Institute for Advanced Research in Chemical Sciences (IAdChem) Universidad Autónoma de Madrid Madrid 28049 Spain

Intelligent Optical Nanomaterials (IONs), Dipartimento di Scienze Molecolari e Nanosistemi (DSMN) Università Ca’ Foscari Venezia Venezia‐Mestre 30170 Italy

Department of Signal Theory and Communications, Telematics and Computing Universidad Rey Juan Carlos Madrid 28943 Spain

Funding

China Scholarship Council · Universidad Autónoma de Madrid · Comunidad de Madrid

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