DataVXAdvanced Optical MaterialsPaper
journal article·2025-06Open access

Quantum Sensing of Lanthandie Binding Tags with Relaxometer of NV Center in Diamond

Zibo Gao, Zhengzhi Jiang, Qiyu Liang, Ruihua He, Van Cuong Mai, Yingwei Tang, Qirong Xiong, Wenting Zhao, Hongwei Duan, Hongliang Sun, Mo Li, Yansong Miao, Weibo Gao

Advanced Optical Materials· Volume 13· Issue 18
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Source abstract

Abstract

Abstract Lanthanide binding tags (LBTs) stand out as a prominent group of fluorescent probes that are extensively utilized in biological detection. However, research on LBTs has predominantly emphasized their fluorescence properties, which frequently compromised by background fluorescence noise. Investigating magnetic properties could optimize detection methodologies that offer enhanced sensitivity and specificity. This study measures the response of a relaxometer based on ensemble nitrogen‐vacancy (NV) centers in diamond to various amounts of LBTs with gadolinium ions, determining the detection limit of LBTs to be 25 fmol. A detection scheme employing the NV relaxometer to detect specific binding between LBTs and target is then proposed and demonstrated. Specifically, the study assesses the relaxometer's response to various concentrations of the interaction between the modified LBTs and Receptor‐Binding Domain (RBD) of SARS‐COVID‐2 spike protein, with the detection threshold reaching ≈2 pmol. The research provides a potential application platform for biomarker detection under picomole concentration by using NV centers to detect the magnetism of LBTs.
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Research context

OpenAlex topics: Diamond and Carbon-based Materials Research · Atomic and Subatomic Physics Research · Carbon Nanotubes in Composites

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore

The Key Laboratory of Bionic Engineering, (Ministry of Education of China) Jilin University Changchun 130022 China

The College of Biological and Agricultural Engineering Jilin University Changchun 130022 China

Department of Chemistry National University of Singapore Singapore 117543 Singapore

School of Biological Sciences Nanyang Technological University Singapore 637551 Singapore

School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore

Yunnan International Joint Laboratory of Bionic Science and Engineering Kunming 650223 China

Institute for Digital Molecular Analytics and Science Nanyang Technological University Singapore 636921 Singapore

School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore

Centre for Quantum Technologies Nanyang Technological University Singapore 117543 Singapore

Funding

National Research Foundation Singapore · Ministry of Education - Singapore · Agency for Science, Technology and Research

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