DataVXAdvanced Optical MaterialsPaper
journal article·2024-03

Closed‐Loop Optogenetic Modulation of Neural Activities in Freely Moving Mice with Multimodal Fibers

Minghui Du, Jiajun Zheng, Yicong Huang, Xiaoli Wang, Yankun Qi, Jianrong Qiu, Lu Huang, Chaoran Ren, Zhuliang Yu, Shifeng Zhou

Advanced Optical Materials· Volume 12· Issue 9
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Source abstract

Abstract

Abstract The precise manipulation of neural activity is of great significance to reveal the function of complex neural circuits in brain, especially the mechanism of neurological disorders such as epilepsy, Parkinson's, and Alzheimer's disease. In the past decades, optogenetics has become a powerful tool to investigate the function of neural circuits due to its unique advantages of cell specificity and high spatiotemporal resolution. However, to date, most optogenetic manipulation has been conducted in an open‐loop fashion. The closed‐loop neural modulation is still an important task. Here, a closed‐loop optogenetic modulation system is developed for ultra‐fast, ‐accurate, and ‐stable manipulation of neural activities in behaving mice. Specifically, this system is mediated by a functional fiber probe with excellent low optical loss (0.052 dB cm−1 at 589 nm) and electrical impedance (5.40 MΩ µm−2 at 1 kHz). In vivo electrophysiology and behavioral experiments demonstrated that the system can be successfully applied for the identification and intervention of seizures in epilepsy mice with high efficiency. It is envision that the closed‐loop manipulation system has promising applications in brain science, neuroscience, and neuromodulation therapies.
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Research context

OpenAlex topics: Photoreceptor and optogenetics research · Neuroscience and Neural Engineering · Neural dynamics and brain function

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China

Institute of Photonics Technology Jinan University Guangzhou 511443 China

Department of Neurosurgery The First Affiliated Hospital of Jinan University Guangzhou 510630 China

School of Automation Science and Engineering South China University of Technology Guangzhou 510640 China

School of Computing Georgia Institute of Technology Atlanta 30322 USA

Guangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 China

Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices Guangzhou 510640 China

College of Optical Science and Engineering State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

Department of Emergency Zhujiang Hospital Southern Medical University Guangzhou 510282 China

Co‐Innovation Center of Neuroregeneration Nantong University Nantong 226019 China

Pazhou Laboratory Guangzhou 510005 China

Funding

National Science Fund for Distinguished Young Scholars · National Natural Science Foundation of China

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