journal article·2025-07Open access

Nanoscale Force Measurement with Optical Tweezers: Applications and Future Prospects in Biophotonics (Advanced Optical Materials 21/2025)

Yinyue Ji, Zhengtian Jin, Jianxing Zhou, Yuhang Peng, Xiaoqi Dai, Yili Zhong, Jinming Zhang, Haoyu Liu, Meiting Wang, Junle Qu, Ho‐Pui Ho, Shuwen Zeng, Yuye Wang, Jiajie Chen, Yonghong Shao

Advanced Optical Materials· Volume 13· Issue 21

Abstract

Nanoscale Force Measurement An optical trapping generated from a Gaussian laser beam traps a microsphere, which interacts with red blood cells, DNA, and proteins, enabling precise force measurements with piconewton-level precision. The fundamental principle of force detection is highlighted by the equation F = kΔx, where F is the force, k is the trap stiffness, and Δx is the displacement of the microsphere. This technique provides a powerful tool for probing biomechanical interactions in nanoscience and biophysics. More details can be found in article 2403140 by Shuwen Zeng, Yuye Wang, Jiajie Chen, and co-workers.
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Research context

OpenAlex topics: Photonic and Optical Devices · Mechanical and Optical Resonators · Orbital Angular Momentum in Optics

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Affiliations

State Key Laboratory of Radio Frequency Heterogeneous Integration Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronics Engineering Shenzhen University Shenzhen 518060 China

Department of Biomedical Engineering The Chinese University of Hong Kong Shatin Hong Kong 999077 China

Light Nanomaterials & Nanotechnologies (L2n) CNRS‐UMR 7076 University of Technology of Troyes Troyes 10000 France

References

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