DataVXAdvanced Optical MaterialsPaper
journal article·2025-01Open access

Cluster and Kill: the Use of Clustering‐Triggered Emission Materials for Singlet Oxygen Photosensitization in Antimicrobial Photodynamic Therapy

Karina Dueñas‐Parro, Oscar Gulias, Montserrat Agut, Felipe de la Cruz‐Martínez, Agustín Lara‐Sánchez, José A. Castro‐Osma, Juan F. García‐Reyes, Antonio Sánchez‐Ruiz, Cristina Martín, Santi Nonell, Roger Bresolí‐Obach

Advanced Optical Materials· Volume 13· Issue 3
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Source abstract

Abstract

Abstract The emergence of light‐based technologies is revolutionizing modern medicine and healthcare by enabling precise disease diagnosis and treatment through various luminescent agents and imaging techniques. Despite challenges like biocompatibility, spectral tuning, and synthesis complexity, the primary issue is the aggregation‐caused quenching of emission on high concentrations or physiological conditions. In light of these problems, Clustering‐Triggered Emission (CTE), which involves the formation of atomic clusters to induce light absorption and the luminescence of unconventional chromophores, represents an all‐in‐one solution to the challenges identified. Given the potential for CTE materials to behave in ways previously only associated with conventional chromophores, it seems reasonable that highly oxidative reactive oxygen species can be formed from CTE excited states. The results demonstrate that it is possible to transfer the excess energy from the CTE long‐lived excited states to molecular oxygen, thereby producing singlet oxygen. It is also noteworthy that over 99.9% of Staphylococcus aureus cells can be eradicated using fluences comparable to those used in traditional systems under violet light irradiation. Uncovering these photophysical properties of CTE opens the door to a revolutionary breakthrough that can disrupt conventional photodynamic therapy and usher in a new era of CTE‐based photosensitizers.
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Research context

Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department de Química Analítica i aplicada Institut Químic de Sarrià – Universitat Ramon Llull Via Augusta 390 Barcelona 08017 Spain

Departament de Bioenginyeria Institut Químic de Sarrià – Universitat Ramon Llull Via Augusta 390 Barcelona 08017 Spain

Departmento de Química Inorgánica Orgánica y Bioquímica‐Centro de Innovación de Química Avanzada (ORFEO‐CINQA) Facultad de Ciencias y Tecnologías Químicas Universidad de Castilla‐la ManchaAvda Camilo José Cela, 10 Ciudad Real 13071 Spain

Analytical Chemical Research Group (FQM 323) Department of Physical and Analytical Chemistry Universidad de Jaén Campus Las Lagunillas edif. B3 Jaén 23071 Spain

Departmento de Química Inorgánica Orgánica y Bioquímica Facultad de Farmacia Universidad de Castilla‐la Mancha Avda Dr. José María Sánchez Ibañez, s/n Albacete 02071 Spain

Instituto de Biomedicina. Complejo de la Facultad de Medicina de Albacete Universidad de Castilla‐la Mancha C/Almansa 14 Albacete 02008 Spain

Departmento de Química Física Facultad de Farmacia Universidad de Castilla‐la Mancha Avda. Dr. José María Sánchez Ibañez, s/n Albacete 02071 Spain

Funding

Universidad de Castilla-La Mancha · Institució Catalana de Recerca i Estudis Avançats · HORIZON EUROPE European Research Council · Junta de Comunidades de Castilla-La Mancha · Ministerio de Ciencia e Innovación

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