DataVXAdvanced Optical MaterialsPaper
journal article·2023-10

Fully Implantable and Retrievable Upconversion Waveguides for Photodynamic Therapy in Deep Tissue

Zhao Shi, Xiaohan Gao, Xue Cai, Hongyou Zhao, Xiuhong Wang, Lingyun Zhao, Lan Yin, He Ding, Xing Sheng

Advanced Optical Materials· Volume 11· Issue 19
Publisher page
Source abstract

Abstract

Abstract The clinical administration of biophotonic approaches, such as photodynamic therapy (PDT), is impeded by the low penetration of visible light in biological tissues. The cooperation of infrared (IR) light with deeper penetration and implantable IR‐to‐visible upconversion materials and devices establishes an effective strategy to generate visible light in deep tissue. In this work, a wirelessly powered upconversion waveguide‐based light source is reported for PDT‐based in vivo cancer treatments in deep tissue. Combining microscale IR‐to‐visible upconversion device arrays and a biocompatible waveguide, the implant exhibits enhanced IR transmission in biological environments and generates upconverted red emission in the target region at a depth >10 mm. The red illumination activates a photosensitizer in 5‐aminolevulinic acid (5‐ALA)‐based PDT treatment, inducing massive apoptosis (>60% cell death) of tumor cells. After implanted in tumor‐bearing mice, the waveguides enable chronic operation for more than two weeks and reveal ideal anti‐tumor efficacies in the PDT process. Finally, the biocompatible waveguide can be retrieved from the tissue, leaving minimal traces after treatments. Such a waveguide implant represents a prospective technique to realize optical‐based biological modulations and medical treatments within the body.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · bioluminescence and chemiluminescence research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electronic Engineering Beijing National Research Center for Information Science and Technology Institute for Precision Medicine Center for Flexible Electronics Technology IDG/McGovern Institute for Brain Research Tsinghua University Beijing 100084 China

Innovative Laboratory of Integrated Traditional Chinese and Western Medicine for Brain Science (Disease) School of Medicine Tsinghua University Beijing 100084 China

Department of Neurosurgery Yuquan Hospital School of Clinical Medicine Tsinghua University Beijing 100084 China

Institute of Engineering Medicine Beijing Institute of Technology Beijing 100081 China

Laboratory for Biomedical Photonics Institute of Laser Engineering Faculty of Materials and Manufacturing Beijing University of Technology Beijing 100021 China

School of Materials Science and Engineering The Key Laboratory of Advanced Materials of Ministry of Education State Key Laboratory of New Ceramics and Fine Processing Center for Flexible Electronics Technology Tsinghua University Beijing 100084 China

Beijing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and Photonics Beijing Institute of Technology Beijing 100081 China

Funding

National Natural Science Foundation of China · Beijing Municipal Natural Science Foundation · China Postdoctoral Science Foundation

References (64)

Show source-provided references
1. Deda D. · J. Braz. Chem. Soc. · 2015 · 26 · 2448
2. 10.1038/nrc107110.1038/nrc1071 ↗
3. 10.3322/caac.2011410.3322/caac.20114 ↗
4. 10.1111/php.1321910.1111/php.13219 ↗
5. 10.1021/cr500419810.1021/cr5004198 ↗
6. 10.1088/0031-9155/53/9/R0110.1088/0031-9155/53/9/R01 ↗
7. 10.1039/C6TB00307A10.1039/C6TB00307A ↗
8. 10.7150/thno.528410.7150/thno.5284 ↗
9. 10.1016/1011-1344(90)85064-410.1016/1011-1344(90)85064-4 ↗
10. 10.1016/j.pdpdt.2010.02.00110.1016/j.pdpdt.2010.02.001 ↗
11. 10.1007/s10103-008-0539-110.1007/s10103-008-0539-1 ↗
12. 10.1038/nature0309510.1038/nature03095 ↗
13. 10.1038/s41551-016-000810.1038/s41551-016-0008 ↗
14. 10.1016/S1572-1000(04)00012-210.1016/S1572-1000(04)00012-2 ↗
15. 10.1038/s41578-019-0167-310.1038/s41578-019-0167-3 ↗
16. 10.1038/nm.293310.1038/nm.2933 ↗
17. 10.1073/pnas.171755211510.1073/pnas.1717552115 ↗
18. 10.1038/s41551-018-0261-710.1038/s41551-018-0261-7 ↗
19. 10.1038/s41598-020-79067-710.1038/s41598-020-79067-7 ↗
20. 10.1038/s41598-019-38554-210.1038/s41598-019-38554-2 ↗
21. 10.1021/acsnano.0c0067510.1021/acsnano.0c00675 ↗
22. 10.1063/5.010281110.1063/5.0102811 ↗
23. 10.1117/1.162824310.1117/1.1628243 ↗
24. 10.1039/D0TB01430C10.1039/D0TB01430C ↗
25. 10.1039/C5NH00073D10.1039/C5NH00073D ↗
26. 10.1038/s44222-022-00002-810.1038/s44222-022-00002-8 ↗
27. 10.1002/adom.20220203910.1002/adom.202202039 ↗
28. 10.1039/C5TB00025D10.1039/C5TB00025D ↗
29. 10.1073/pnas.200220111710.1073/pnas.2002201117 ↗
30. 10.1021/cr020357g10.1021/cr020357g ↗
31. 10.1039/C5CS90009C10.1039/C5CS90009C ↗
32. 10.1021/cr400478f10.1021/cr400478f ↗
33. 10.1021/jacs.1c1042510.1021/jacs.1c10425 ↗
34. 10.1039/C4CS00188E10.1039/C4CS00188E ↗
35. 10.1038/s41377-022-00860-210.1038/s41377-022-00860-2 ↗
36. 10.1002/adom.20170098110.1002/adom.201700981 ↗
37. 10.1038/nnano.2015.25110.1038/nnano.2015.251 ↗
38. 10.1038/nphoton.2015.22610.1038/nphoton.2015.226 ↗
39. 10.1038/nnano.2013.14610.1038/nnano.2013.146 ↗
40. 10.1021/acsnano.5b0532910.1021/acsnano.5b05329 ↗
41. 10.1016/j.biomaterials.2018.02.02910.1016/j.biomaterials.2018.02.029 ↗
42. 10.1016/j.biomaterials.2017.07.01710.1016/j.biomaterials.2017.07.017 ↗
43. 10.1021/acs.nanolett.7b0433910.1021/acs.nanolett.7b04339 ↗
44. 10.1002/adma.20200145910.1002/adma.202001459 ↗
45. 10.1073/pnas.180206411510.1073/pnas.1802064115 ↗
46. 10.1038/s41377-022-00825-510.1038/s41377-022-00825-5 ↗
47. http://www.norlandprod.com/adhesives/noa%2065.html(accessed: August 2023).
48. 10.1073/pnas.88.4.158010.1073/pnas.88.4.1580 ↗
49. 10.1016/j.jphotobiol.2019.11158610.1016/j.jphotobiol.2019.111586 ↗
50. 10.1007/s11060-019-03103-410.1007/s11060-019-03103-4 ↗
51. 10.1002/lsm.2080810.1002/lsm.20808 ↗
52. Bozkurt A. · Biomed. Eng. · 2004 · 3 · 9
53. 10.1111/j.1600-0781.2010.00507.x10.1111/j.1600-0781.2010.00507.x ↗
54. 10.1016/S1470-2045(06)70665-910.1016/S1470-2045(06)70665-9 ↗
55. 10.1002/lsm.2293310.1002/lsm.22933 ↗
56. 10.1038/s41416-019-0516-410.1038/s41416-019-0516-4 ↗
57. 10.1038/s41467-022-28539-710.1038/s41467-022-28539-7 ↗
58. 10.1126/science.123243710.1126/science.1232437 ↗
59. 10.1073/pnas.192007311710.1073/pnas.1920073117 ↗
60. 10.1038/s41565-022-01189-y10.1038/s41565-022-01189-y ↗
61. 10.1038/s41467-020-19945-w10.1038/s41467-020-19945-w ↗
62. 10.1002/aenm.20170303510.1002/aenm.201703035 ↗
63. https://lambdares.com/tracepro (accessed: August 2023)
64. https://www.comsol.com (accessed: August 2023)