DataVXAdvanced Optical MaterialsPaper
journal article·2025-01Open access

TADF‐Emitting Nanoparticles for Application as Probes in Time‐Resolved Imaging and 1O2 Photosensitizers

Ana Marta Diniz, Carina I. C. Crucho, Maria J. Ruedas‐Rama, Angel Orte, Cristina J. Dias, Mani Outis, Sandra N. Pinto, M. Amparo F. Faustino, Mário Nuno Berberan‐Santos, João Avó

Advanced Optical Materials· Volume 13· Issue 2
Publisher pageOpen full text
Source abstract

Abstract

Abstract Organic Thermally Activated Delayed Fluorescence (TADF) molecules are luminescent compounds capable of harvesting energy from triplet states without using heavy metals. This process results in oxygen‐sensitive, long‐lived delayed emission, suitable for developing optical probes for time‐gated cell imaging, oxygen sensors, and singlet oxygen photosensitizers. Despite their potential, the use of TADF emitters in these applications is hindered by poor performance in polar media and the challenge of balancing high photoluminescence quantum yields, long emission lifetimes, and high triplet formation quantum yields. In this study, novel TADF emitters are developed based on 1,8‐naphthalimide (NI) dyes, and how encapsulation in polymeric nanoparticles can enhance their performance in aqueous media is demonstrated. The resulting nanomaterials exhibit high delayed‐to‐prompt emission ratios, long delayed fluorescence lifetimes, and exceptional applicability in time‐resolved imaging. The singlet oxygen photosensitization capabilities of the TADF nanomaterials in the photodegradation of phenol, exploring a Förster Resonance Energy Transfer (FRET) system that improved the efficiency, are also assessed. These findings highlight the promising potential of TADF nanomaterials for diverse applications, including photodegradation of pollutants, cellular imaging, and biosensing.
Source: crossref · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Luminescence and Fluorescent Materials · Organic Light-Emitting Diodes Research · Lanthanide and Transition Metal Complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

iBB—Institute for Bioengineering and Biosciences Department of Bioengineering and i4HB—Institute for Health and Bioeconomy at Instituto Superior Técnico University of Lisbon Av. Rovisco Pais Lisbon 1049‐001 Portugal

Associate Laboratory i4HB – Institute for Health and Bioeconomy and UCIBIO – Applied Molecular Biosciences Unit Department of Life Sciences NOVA School of Science and Technology NOVA University Lisbon Caparica 2819‐516 Portugal

Nanoscopy‐UGR Laboratory Departamento de Fisicoquímica Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente Facultad de Farmacia Campus Cartuja University of Granada Granada 18071 Spain

LAQV‐ REQUIMTE Department of Chemistry University of Aveiro Campus Universitário de Santiago Aveiro 3810‐193 Portugal

Institute of Biomedicine (iBiMED) Department of Medical Sciences University of Aveiro Campus Universitário de Santiago Aveiro 3810‐193 Portugal

LAQV‐REQUIMTE Departamento de Química NOVA School of Science and Technology NOVA School of Science and Technology NOVA University of Lisbon Caparica 2829‐516 Portugal

Funding

Agencia Estatal de Investigación

References (57)

Show source-provided references
1. 10.1038/nature1168710.1038/nature11687 ↗
2. 10.1002/adma.20130075310.1002/adma.201300753 ↗
3. 10.1002/adma.20140253210.1002/adma.201402532 ↗
4. 10.1002/adfm.20210580510.1002/adfm.202105805 ↗
5. 10.1002/anie.20201207010.1002/anie.202012070 ↗
6. 10.1002/adma.20160544410.1002/adma.201605444 ↗
7. 10.1088/2050-6120/aa537e10.1088/2050-6120/aa537e ↗
8. 10.1039/C6CS00368K10.1039/C6CS00368K ↗
9. 10.1021/ja502292p10.1021/ja502292p ↗
10. 10.1021/jacs.8b0843810.1021/jacs.8b08438 ↗
11. 10.1039/C8SC01485J10.1039/C8SC01485J ↗
12. 10.1002/advs.20180172910.1002/advs.201801729 ↗
13. 10.1038/s41551-016-001010.1038/s41551-016-0010 ↗
14. 10.1002/jbio.20150027110.1002/jbio.201500271 ↗
15. 10.1039/c0cs00114g10.1039/c0cs00114g ↗
16. 10.3389/fchem.2020.0040410.3389/fchem.2020.00404 ↗
17. 10.1002/adom.20190218710.1002/adom.201902187 ↗
18. 10.1021/acsami.9b2246410.1021/acsami.9b22464 ↗
19. 10.1039/C6CC05130H10.1039/C6CC05130H ↗
20. 10.1021/acsami.9b1455210.1021/acsami.9b14552 ↗
21. 10.1039/D1TB00719J10.1039/D1TB00719J ↗
22. 10.1039/D0CC08323B10.1039/D0CC08323B ↗
23. 10.1016/j.ccr.2020.21354510.1016/j.ccr.2020.213545 ↗
24. 10.1039/D2QI01112C10.1039/D2QI01112C ↗
25. 10.1016/j.cclet.2019.08.03210.1016/j.cclet.2019.08.032 ↗
26. 10.1021/acsnano.3c0510610.1021/acsnano.3c05106 ↗
27. 10.3389/fchem.2021.74392810.3389/fchem.2021.743928 ↗
28. 10.1016/j.msec.2019.11052810.1016/j.msec.2019.110528 ↗
29. 10.1021/accountsmr.3c0012410.1021/accountsmr.3c00124 ↗
30. 10.1002/advs.20210297010.1002/advs.202102970 ↗
31. 10.1021/acs.chemmater.4c0048210.1021/acs.chemmater.4c00482 ↗
32. 10.1039/C9NJ01945F10.1039/C9NJ01945F ↗
33. 10.3389/fchem.2020.0022910.3389/fchem.2020.00229 ↗
34. 10.1002/smll.20210621510.1002/smll.202106215 ↗
35. 10.1002/advs.20160016610.1002/advs.201600166 ↗
36. 10.1002/adma.20170496110.1002/adma.201704961 ↗
37. Tang G. · J. Phys. Chem. · 2019 · 123
38. 10.1016/j.dyepig.2019.04.07110.1016/j.dyepig.2019.04.071 ↗
39. 10.1016/j.orgel.2020.10601210.1016/j.orgel.2020.106012 ↗
40. 10.1002/anie.20240071210.1002/anie.202400712 ↗
41. 10.1021/jacs.1c0629010.1021/jacs.1c06290 ↗
42. 10.1021/acsami.0c0525710.1021/acsami.0c05257 ↗
43. 10.1021/acs.jpcb.0c0411510.1021/acs.jpcb.0c04115 ↗
44. 10.3762/bjoc.19.7910.3762/bjoc.19.79 ↗
45. 10.6023/A1411079510.6023/A14110795 ↗
46. 10.1021/acsami.0c1593610.1021/acsami.0c15936 ↗
47. 10.1039/D3NJ04201D10.1039/D3NJ04201D ↗
48. 10.3390/photochem203003410.3390/photochem2030034 ↗
49. 10.1002/adfm.20180005110.1002/adfm.201800051 ↗
50. 10.1007/4243_2018_410.1007/4243_2018_4 ↗
51. 10.1021/nn402581q10.1021/nn402581q ↗
52. 10.1016/j.snb.2024.13613610.1016/j.snb.2024.136136 ↗
53. García Fresnadillo D. · 2016
54. 10.1111/php.1286010.1111/php.12860 ↗
55. 10.1039/f1980760180110.1039/f19807601801 ↗
56. 10.1098/rspa.1956.010210.1098/rspa.1956.0102 ↗
57. 10.1101/pdb.prot08737910.1101/pdb.prot087379 ↗