DataVXAdvanced Optical MaterialsPaper
journal article·2024-05

Activatable Nanoprobes for Dual‐Modal NIR‐II Photoacoustic and Fluorescence Imaging of Hydrogen Sulfide in Colon Cancer

Shuhan Wang, Xuan Zhang, Yiping Zhang, Kang Zhu, Xing Liu, Jieping Zhang, Guoyu Wang, Daojia Liu, Kuaile Zhao, Xin Wang, Junqiang Chen, Jibin Song

Advanced Optical Materials· Volume 12· Issue 13
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Source abstract

Abstract

Abstract High hydrogen sulfide (H2S) expression has been shown to play a crucial role in tumor growth and proliferation in colon cancer. So far, most probes used for monitoring H2S offer single‐modal imaging, which makes the collection of accurate information for tumor diagnosis difficult. In the present study, a novel dual‐modal imaging probe in the second near‐infrared (NIR‐II, 950‐1700) window is proposed and constructed by coating a uniform shell of polydopamine (PDA) on the surface of cuprous oxide (Cu2O)‐conjugated downconversion nanoparticles (DCNPs). Of note, DCNP‐Cu2O@PDA is in the “on” state, with emission centered at 1550 nm (irradiation using a 980nm laser) in non‐neoplastic tissues. Colon tumors with endogenous H2S overexpression can induce the in situ transformation of Cu2O to copper sulfide (Cu2‐XS）. Owing to the competitive absorption between Cu2‐XS and DCNPs at a wavelength of 980 nm, the generated DCNP‐Cu2‐XS@PDA exhibits a quenched NIR‐II fluorescence (FL) signal. Meanwhile, Cu2‐XS exhibits a strong absorbance at 1250 nm, enhancing the NIR‐II photoacoustic (PA) signal accompanied by NIR‐II FL attenuation. The switching in PA and FL signals at the tumor site offered “double assurances” for the accurate monitoring of H2S.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Sulfur Compounds in Biology · Gas Sensing Nanomaterials and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Chemistry Fuzhou University Fuzhou 350108 P. R. China

Department of Radiation Oncology, Department of Nuclear Medicine, Clinical Oncology School of Fujian Medical Univercity Fujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center) Fuzhou 350014 P. R. China

State Key Laboratory of Chemical Resource Engineering, College of Chemistry Beijing University of Chemical Technology Beijing 100029 P. R. China

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Clinical Research Center for Radiation Oncology Shanghai Key Laboratory of Radiation Oncology Shanghai 200032 P. R. China

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College No.17 Panjiayuan Nanli Chaoyang Beijing 100021 P. R. China

Funding

Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Natural Science Foundation of Fujian Province · China Postdoctoral Science Foundation

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