DataVXAdvanced Optical MaterialsPaper
journal article·2023-01

Multimaterial Glass Fiber Probe for Deep Neural Stimulation and Detection

Yi Dai, Minghui Du, Lu Huang, Jiajun Zheng, Lei Wei, Jianrong Qiu, Chaoran Ren, Shifeng Zhou

Advanced Optical Materials· Volume 11· Issue 2
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Source abstract

Abstract

Abstract The ability for simultaneous modulation and monitoring of neural activities in deep tissues and at the single‐cell level merits significant scientific and technological potential, yet is met with limited success using conventional probes. Here, a new type of tiny multimaterial glass fiber probe is proposed and successfully constructed with the combination of robust mechanical response, strong light‐delivering ability, and excellent electrochemical properties, based on high throughput and scalable co‐drawing strategy. Guided by the multimaterial integration principle, the configuration of the probes can be rationally tuned including their material combination, physical size, the number and spatial distribution of the electrode, and even the waveguide structure. The bending stiffness, optical loss, and electrical impedance can be controlled to be larger than 4900 N m−1 and as small as 0.01306 dB cm−1 and 19.63 MΩ µm2 at 1 kHz, respectively. To prove the utility, it is demonstrated that the probes allow for simultaneous deep neural stimulation and detection for more than 2 weeks at a single cellular level. This work not only promotes the development of neuroscience and brain science through the ability to manipulate neural circuits in the deep brain but also provides new directions for expanding the scope of functional fibers.
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Research context

Ceramics & glasses

OpenAlex topics: Neuroscience and Neural Engineering · Photoreceptor and optogenetics research · Advanced Memory and Neural Computing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China

Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices Guangzhou 510640 China

School of Automation Science and Engineering South China University of Technology Guangzhou 510640 China

Guangdong‐Hongkong‐Macau Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangzhou 510632 China

School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore

College of Optical Science and Engineering State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

Funding

National Science Fund for Distinguished Young Scholars · National Natural Science Foundation of China · China Postdoctoral Science Foundation · Fundamental Research Funds for the Central Universities

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