DataVXAdvanced Optical MaterialsPaper
journal article·2024-03Open access

Near‐Infrared and Visible Dual‐Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes

Yik‐Hoi Yeung, Ho‐Fai Chau, Hei‐Yui Kai, Wanqi Zhou, Kaitlin Hao‐Yi Chan, Waygen Thor, Loïc J. Charbonnière, Fan Zhang, Yong Fan, Yue Wu, Ka‐Leung Wong

Advanced Optical Materials· Volume 12· Issue 9
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Source abstract

Abstract

Abstract The synthetic difficulty of target‐specific lanthanide complexes, despite their unique characteristics, limits their use in in vitro/ in vivo studies and biomedical applications. With commercially available and affordable reagents, a facile synthetic approach is developed to modularly deploy nitrobenzoxadiazole and neodymium complexes onto bioactive peptides. The yielded probes show observable neodymium emission with specific localization to corresponding biotargets in vitro, which became the first example of a stable, water‐soluble, and target‐specific neodymium(III) complex applicable for in vitro imaging with detectable brightness.
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Research context

Biomaterials

OpenAlex topics: Lanthanide and Transition Metal Complexes · Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd Hung Hom Hong Kong, SAR China

Department of Chemistry Hong Kong Baptist University 224 Waterloo Rd, Kowloon Tong Kowloon Hong Kong, SAR China

Equipe de synthèse pour l'analyse (SynPA) Institut Pluridisciplinaire Hubert Curien (IPHC) Département des sciences analytiques (DSA) – UMR 7178 CNRS/Université de Strasbourg ECPM Bâtiment R1N0, 25, rue Becquerel, Cedex‐2 Strasbourg 67087 France

Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University 2005 Songhu Road, Yangpu Shanghai 200438 China

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