Structural Modification Orientated Multifunctional AIE Fluorescence Probes: Organelles Imaging and Effective Photosensitizer for Photodynamic Therapy
Source abstract
Abstract
Abstract Luminogens with aggregation‐induced emission feature (AIEgens) are highly demanded because of its excellent performance in fluorescent bioprobes. In this work, three AIEgens based on tetraphenylethylene isoquinolinium (TPE‐IQ) derivatives by introducing different electron donor and sterically hindered groups to replace the phenyl ring of the isoquinolinium core are prepared in a one‐pot reaction with a high yield and characterized systematically. By the analysis of photophysical properties and theoretical calculations, the structure‐property relationships among them become clear. Although they all inherit AIE feature as expected, these similar structural AIEgens present different organelle‐targets, which is attributed to their different cellular uptake way and energy barrier to cell membrane by detailed experiments. In addition, these TPE‐IQ‐based AIEgens are potential candidates for photodynamic therapy originating from their activities of generating reactive oxygen species under visible light irradiation.
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Research context
OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Molecular Sensors and Ion Detection
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Aggregation‐Induced Emission Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China
Department of Urology The First Affiliated Hospital of Soochow University 188 Shizi RD Suzhou 215006 China
HKUST‐Shenzhen Research Institute Shenzhen 518057 China
Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Clear Water Bay Kowloon 999077 Hong Kong China
Funding
National Natural Science Foundation of China · Innovation and Technology Commission - Hong Kong · Fundamental Research Funds for the Central Universities
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