DataVXAdvanced Optical MaterialsPaper
journal article·2019-07

Bi‐Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics

Alexander Yu. Kharin, Vladimir V. Lysenko, Andrei Rogov, Yuri V. Ryabchikov, Alain Geloen, Igor Tishchenko, Olivier Marty, Peter G. Sennikov, Roman A. Kornev, Irina N. Zavestovskaya, Andrei V. Kabashin, Victor Yu. Timoshenko

Advanced Optical Materials· Volume 7· Issue 13
Publisher page
Source abstract

Abstract

Abstract Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer a series of breakthrough hyperthermia‐based therapies under near‐infrared, radiofrequency, ultrasound, etc., excitation, but the size range to sensitize these therapies is typically too large (>10 nm) to enable efficient imaging functionality based on photoluminescence properties of quantum‐confined excitonic states. Here, it is shown that large Si nanoparticles (NPs) are capable of providing two‐photon excited luminescence (TPEL) and second harmonic generation (SHG) responses, much exceeding that of smaller Si NPs, which promises their use as probes for bi‐modal nonlinear optical bioimaging. It is finally demonstrated that the combination of TPEL and SHG channels makes possible efficient tracing of both separated Si NPs and their aggregations in different cell compartments, while the resolution of such an approach is enough to obtain 3D images. The obtained bi‐modal contrast provides lacking imaging functionality for large Si NPs and promises the development of novel cancer theranostic modalities on their basis.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Silicon Nanostructures and Photoluminescence · Quantum Dots Synthesis And Properties · Nanowire Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Engineering Physics for Biomedicine (Phys‐Bio) MEPhI Kashirskoe sh. 31 115409 Moscow Russia

Laboratoire de Recherche en Cardiovasculaire, Métabolisme, Diabétologie et Nutrition Université de Lyon INSA Lyon 11 Avenue Jean Capelle F‐69621 Villeurbanne France

Institut des Nanotechnologies de Lyon Université de Lyon UMR‐5270, site INSA F‐69621 Villeurbanne France

Department of Applied Physics Université de Genève 22 Chemin de Pinchat CH‐1211 Geneva Switzerland

Laboratoire LP3 Aix‐Marseille Univ. CNRS F‐13009 Marseille France

Lebedev Physical Institute of the Russian Academy of Sciences Leninskiy Pr. 53 119991 Moscow Russia

Institute of Physics of the Czech Academy of Sciences HiLASE Centre Za Radnicí 828 25241 Dolní Brˇežany Czech Republic

R&D Department KM Labs LLC 1‐3 Severo‐Syretskaya str. 04136 Kiev Ukraine

Institut des Nanotechnologies de Lyon Université de Lyon UMR‐5270, site UCBL F‐69622 Villeurbanne France

Laboratory of Plasmachemistry G.G. Devyatykh Institute of Chemistry of High‐Purity Substances of the Russian Academy of Sciences Tropinin Str. 49 603950 Nizhny Novgorod Russia

Physics Department Lomonosov Moscow State University Leninskie Gory 1 119991 Moscow Russia

Funding

Centre National de la Recherche Scientifique · Russian Science Foundation · Ministerstwo Nauki i Szkolnictwa Wyższego

References (34)

Show source-provided references
1. 10.1038/nmat239810.1038/nmat2398 ↗
2. 10.1038/srep2540010.1038/srep25400 ↗
3. 10.1007/978-3-642-54668-610.1007/978-3-642-54668-6 ↗
4. Prasad P. N. · 2012
5. 10.2217/nnm-2016-022810.2217/nnm-2016-0228 ↗
6. 10.1016/j.biomaterials.2009.02.00810.1016/j.biomaterials.2009.02.008 ↗
7. 10.1021/nn700319z10.1021/nn700319z ↗
8. 10.1038/ncomms332610.1038/ncomms3326 ↗
9. 10.1039/C6NR01437B10.1039/C6NR01437B ↗
10. 10.1002/adma.20170330910.1002/adma.201703309 ↗
11. 10.1002/cplu.20160020710.1002/cplu.201600207 ↗
12. 10.1002/pssb.20170050110.1002/pssb.201700501 ↗
13. 10.1038/srep2473210.1038/srep24732 ↗
14. 10.1038/srep0703410.1038/srep07034 ↗
15. 10.1039/b808500e10.1039/b808500e ↗
16. 10.1063/1.482914810.1063/1.4829148 ↗
17. 10.1021/acsnano.5b0132010.1021/acsnano.5b01320 ↗
18. 10.1063/1.359961810.1063/1.3599618 ↗
19. 10.1007/s10967-015-4192-410.1007/s10967-015-4192-4 ↗
20. 10.1039/c3tb20285b10.1039/c3tb20285b ↗
21. 10.1039/C6TB02623K10.1039/C6TB02623K ↗
22. 10.1186/2251-7235-6-610.1186/2251-7235-6-6 ↗
23. 10.1038/nphoton.2010.18510.1038/nphoton.2010.185 ↗
24. 10.1166/jno.2013.147310.1166/jno.2013.1473 ↗
25. Golovan L. A. · Tech. Phys. Lett. · 1994 · 20 · 334
26. 10.1103/PhysRevB.84.16531610.1103/PhysRevB.84.165316 ↗
27. 10.1103/PhysRevA.46.161410.1103/PhysRevA.46.1614 ↗
28. 10.1007/s00340-003-1121-y10.1007/s00340-003-1121-y ↗
29. Shen Y. R. · 1984
30. 10.1364/OE.20.02627510.1364/OE.20.026275 ↗
31. 10.1371/journal.pone.014159310.1371/journal.pone.0141593 ↗
32. 10.3390/ijms1709153610.3390/ijms17091536 ↗
33. 10.1002/adem.20108009110.1002/adem.201080091 ↗
34. 10.1088/1361-6528/aa5b7c10.1088/1361-6528/aa5b7c ↗