Quaternary Ammonium Salt Based NIR‐II Probes for In Vivo Imaging

Chunrong Qu; Yuling Xiao; Hui Zhou; Bingbing Ding; Anguo Li; Jiacheng Lin; Xiaodong Zeng; Hao Chen; Kun Qian; Xiao Zhang; Wei Fang; Junzhu Wu; Zixin Deng; Zhen Cheng; Xuechuan Hong

doi:10.1002/adom.201900229

journal article·2019-08Open access

Quaternary Ammonium Salt Based NIR‐II Probes for In Vivo Imaging

Chunrong Qu, Yuling Xiao, Hui Zhou, Bingbing Ding, Anguo Li, Jiacheng Lin, Xiaodong Zeng, Hao Chen, Kun Qian, Xiao Zhang, Wei Fang, Junzhu Wu, Zixin Deng, Zhen Cheng, Xuechuan Hong

Advanced Optical Materials· Volume 7· Issue 15

Publisher page Open full text

Source abstract

Abstract

Abstract Traditional luminescent materials including fluorescent probes suffer from notorious aggregation‐caused quenching in aqueous solutions. Although several approaches such as the aggregation‐induced emission effect have been developed, it remains a significant challenge to identify an effective and efficient strategy to resolve this issue. Herein, quaternary ammonium salts Q8PBn and Q8PNap as a novel class of bright near infrared window II (NIR‐II, 1000–1700 nm) probes are designed and synthesized, and the twisted intramolecular charge transfer formation at the excited state can be effectively suppressed for the newly designed probes. Furthermore, Q8PNap complexation with fetal bovine serum (Q8PNap/FBS) significantly increases the quantum yield by ≈32‐fold compared with PEGylated tertiary amine Q8P, and Q8PNap/FBS is successfully used to achieve high spatial and temporal resolution imaging of hind limb vasculature, lymphatic system, and small tumor metastasis, as well as precise NIR‐II imaging‐guided tumor and lymph node surgery in small animal models for the first time.

Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Virology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals Wuhan University School of Pharmaceutical Sciences Wuhan 430071 China

Molecular Imaging Program at Stanford (MIPS) Bio‐X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University CA 94305‐5344 USA

Shenzhen Institute of Wuhan University Shenzhen 518057 China

Hubei Provincial Key Laboratory of Developmentally Originated Disease Center for Experimental Basic Medical Education Wuhan University Wuhan 430071 China

Funding

National Natural Science Foundation of China-Yunnan Joint Fund · U.S. Department of Energy · Fundamental Research Funds for the Central Universities

References (47)

Show source-provided references

1. 10.1021/ja208883h10.1021/ja208883h ↗

2. 10.1134/S000635091402007910.1134/S0006350914020079 ↗

3. 10.1002/adma.20170685610.1002/adma.201706856 ↗

4. 10.1039/c1cs15113d10.1039/c1cs15113d ↗

5. 10.1186/1754-1611-4-1110.1186/1754-1611-4-11 ↗

6. 10.1021/jacs.7b1033410.1021/jacs.7b10334 ↗

7. 10.1021/ja807561710.1021/ja8075617 ↗

8. 10.1038/nmeth.325610.1038/nmeth.3256 ↗

9. 10.1021/jacs.6b0392410.1021/jacs.6b03924 ↗

10. 10.1038/nm.299510.1038/nm.2995 ↗

11. 10.1038/nphoton.2014.16610.1038/nphoton.2014.166 ↗

12. 10.1038/nnano.2009.29410.1038/nnano.2009.294 ↗

13. 10.1021/cm400812v10.1021/cm400812v ↗

14. 10.1002/adfm.20130326310.1002/adfm.201303263 ↗

15. 10.1016/j.biomaterials.2013.10.01010.1016/j.biomaterials.2013.10.010 ↗

16. 10.1002/anie.20110108410.1002/anie.201101084 ↗

17. 10.1021/ja909490r10.1021/ja909490r ↗

18. 10.1021/nn301218z10.1021/nn301218z ↗

19. 10.1002/adma.20150227210.1002/adma.201502272 ↗

20. Zhang F. · Angew. Chem., Int. Ed. · 2019 · 131 · 110.1002/ange.201813481 ↗

21. 10.1002/anie.20180288910.1002/anie.201802889 ↗

22. 10.1038/nmat447610.1038/nmat4476 ↗

23. 10.1039/C6SC01561A10.1039/C6SC01561A ↗

24. 10.1002/adma.20160070610.1002/adma.201600706 ↗

25. 10.1073/pnas.161799011410.1073/pnas.1617990114 ↗

26. 10.1039/C8SC03751E10.1039/C8SC03751E ↗

27. 10.1002/adma.20160549710.1002/adma.201605497 ↗

28. 10.1039/C7SC00251C10.1039/C7SC00251C ↗

29. 10.1002/anie.20180122610.1002/anie.201801226 ↗

30. 10.1021/acs.jmedchem.8b0168210.1021/acs.jmedchem.8b01682 ↗

31. 10.1039/C8SC04363A10.1039/C8SC04363A ↗

32. 10.1039/C7SC04774F10.1039/C7SC04774F ↗

33. 10.1002/anie.20161230110.1002/anie.201612301 ↗

34. 10.1002/anie.20170697410.1002/anie.201706974 ↗

35. 10.1016/j.biomaterials.2018.04.03710.1016/j.biomaterials.2018.04.037 ↗

36. 10.1002/adfm.20170345110.1002/adfm.201703451 ↗

37. 10.1002/adhm.20180058910.1002/adhm.201800589 ↗

38. 10.1039/C8CC10286D10.1039/C8CC10286D ↗

39. 10.1007/s11426-018-9341-710.1007/s11426-018-9341-7 ↗

40. 10.1021/acs.jproteome.8b0018110.1021/acs.jproteome.8b00181 ↗

41. 10.1016/j.cclet.2018.08.00910.1016/j.cclet.2018.08.009 ↗

42. 10.1002/jcc.2288510.1002/jcc.22885 ↗

43. 10.1038/ncomms1526910.1038/ncomms15269 ↗

44. 10.1245/s10434-009-0594-210.1245/s10434-009-0594-2 ↗

45. 10.1038/nrc222910.1038/nrc2229 ↗

46. 10.1002/ange.20150862610.1002/ange.201508626 ↗

47. 10.7150/thno.1708510.7150/thno.17085 ↗