Unveiling Tunable “Ghost” to “Non‐Ghost” Matrix Transition Facilitated Through Green Bio‐Ionic Liquid (BIL) Resins Using CPIP‐3D Printing

ABSTRACT Vat‐photopolymerization‐based Controlled Photonic Intelligent Production (CPIP) 3D printing offers precision and versatility for pharmaceutical additive manufacturing, but is limited by non‐degradable commercial resins and the use of toxic post‐processing solvents. We developed innovative photopolymerizable BIL resins, blending choline methacrylate (Ch‐MA), serving as both solvent and monomer, with choline ibuprofenate (Ch‐Ibu) at 10% w/v and 20% w/v . The resulting BIL resins exhibited dynamic, Ch‐Ibu concentration‐dependent supramolecular interactions and were successfully printed via CPIP‐3D printing. The fabricated printlets were characterized for physicochemical, mechanical, erosion, and in vitro drug‐release properties. By tuning Ch‐MA and Ch‐Ibu ratios, we achieved a controllable transition from a swellable “ghost” matrix (3DP10) to a fully erodible “non‐ghost” transition (3DP20). Both formulations demonstrated stability under acidic conditions; however, 3DP10 swelled at pH 6.8, whereas 3DP20 eroded completely within 12 h. In vitro studies revealed pH‐responsive release, with <20% ibuprofen release at pH 1.2 up to 2.0 h and enhanced release at pH 6.8, reaching ∼80% (3DP10) and ∼100% (3DP20) within 24 h. Drug release kinetics confirmed swelling‐mediated release from the 3DP10 matrix (n = 0.74) and erosion‐controlled release from the 3DP20 matrix (n = 1.05). This study demonstrates the potential of BIL‐based, solvent‐ and photo‐crosslinker‐free resins for personalized, biodegradable oral dosage forms via VPP‐based CPIP 3D printing.