DataVXAdvanced Materials TechnologiesPaper
journal article·2023-12Open access

Modeling the Osteogenic Potential of Decellularized Human Bone Particles by Tuning their Size Distribution Through a Sonic Microfragmentation Approach (Adv. Mater. Technol. 24/2023)

Alessio Bucciarelli, Alessandro Pedranz, Laura Gambari, Mauro Petretta, Leonardo Vivarelli, Dante Dallari, Brunella Grigolo, Devid Maniglio, Francesco Grassi

Advanced Materials Technologies· Volume 8· Issue 24
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Source abstract

Abstract

Bone Allografts In article 2300635, Alessio Bucciarelli, Devid Maniglio, Francesco Grassi, and co-workers develop a method to generate microparticles from human cortical decellularized bone based on an ultrasonication approach. Both particle diameter and Alkaline Phosphatase activity are tunable according to the ultrasonication parameters. By evaluating the correlations among different outcomes, an inverse linear correlation between the particle size and the biological properties are found.
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Research context

OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · Spectroscopy Techniques in Biomedical and Chemical Research

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Affiliations

Laboratorio RAMSES IRCCS Istituto Ortopedico Rizzoli Via di Barbiano 1/10 Bologna 40136 Italy

Industrial Engineering Department and Biotech Research Center Italian and European Institute of Excellence on Tissue Engineering and Regenerative Medicine Via Delle Regole 101 Trento 38123 Italy

RegenHU SA Z.I. du Vivier 22 Villaz‐St‐Pierre 1690 Switzerland

Reconstructive Orthopaedic Surgery and Innovative Techniques—Musculoskeletal Tissue Bank IRCCS Istituto Ortopedico Rizzoli Via Giulio Cesare Pupilli, 1 Bologna 40136 Italy

References

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