DataVXAdvanced Materials TechnologiesPaper
journal article·2023-11Open access

Intervertebral Disc‐on‐a‐ChipMF: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Media Flow (Adv. Mater. Technol. 21/2023)

Wanqing Xie, Yuan Xing, Li Xiao, Pu Zhang, Richard Oh, Yangpu Zhang, Xiaoyu Yu, Yi He, Eunha G Oh, Ruofan Cao, Melur K Ramasubramanian, Yong Wang, Li Jin, Jose Oberhozler, Xudong Li

Advanced Materials Technologies· Volume 8· Issue 21
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Source abstract

Abstract

Organ on a Chip In article number 2300606, Jose Oberhozler, Xudong Li, and co-workers develop an innovative and robust platform -Intervertebral Disc-on-a-ChipMF. The image illustrates the system's ability to facilitate dynamic fluid exchange and controlled mechanical loading for discs within a microfluidic biochip. By regulating these essential factors, the system successfully mimics the in vivo microenvironment, thereby demonstrating its promising potential for advancing biological and pathological research of intervertebral disc.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Spine and Intervertebral Disc Pathology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedic Surgery University of Virginia Charlottesville VA 22908 USA

Department of Surgery University of Virginia 345 Cripell Drive Charlottesville VA 22908 USA<?vsp -16pt?>

Department of Mechanical and Aerospace Engineering University of Virginia 122 Engineer's Way Charlottesville VA 22904 USA

Department of Orthopaedic Surgery Beijing Chaoyang Hospital Capital Medical University Beijing 100069 China

Department of BioMolecular Science University of Mississippi Oxford MS 38677 USA

Department of Visceral Surgery and Transplantation University of Zurich Hospital Zürich 8091 Switzerland

Department of Biomedical Engineering University of Virginia Charlottesville VA 22904 USA<?vsp 3.8pc?>

References

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