journal article·2023-09Open access

High‐Throughput CRISPR/Cas9 Mediated Gene Editing of Primary Human T Cells in a Microfluidic Device for Cellular Therapy Manufacturing (Adv. Mater. Technol. 17/2023)

Michaela Welch, Deborah A. Flusberg, Peter Hsi, Nerses J. Haroutunian, Jose A. Santos, Ernest S. Kim, Stacey Markovic, Jonathan R. Coppeta, Charles A. Lissandrello, Jenna L. Balestrini, Vishal Tandon

Advanced Materials Technologies· Volume 8· Issue 17

Abstract

Cellullar Therapy Manufacturing T cells moving through a microfluidic device are electroporated in continuous-flow for high-throughput cellular therapy manufacturing, as reported by Vishal Tandon and co-workers in article 2300275. The combination of high throughput and high performance enables the scale of processing required for future “off-the-shelf” allogeneic cellular therapies.
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Research context

OpenAlex topics: CAR-T cell therapy research

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Affiliations

Bioengineering Division The Charles Stark Draper Laboratory, Inc. Cambridge MA 02139 USA

References

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