DataVXAdvanced Materials TechnologiesPaper
journal article·2021-05

Targeted Chemotherapy: Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump (Adv. Mater. Technol. 5/2021)

Linda Waldherr, Maria Seitanidou, Marie Jakešová, Verena Handl, Sophie Honeder, Marta Nowakowska, Tamara Tomin, Meysam Karami Rad, Tony Schmidt, Joachim Distl, Ruth Birner‐Gruenberger, Gord von Campe, Ute Schäfer, Magnus Berggren, Beate Rinner, Martin Asslaber, Nassim Ghaffari‐Tabrizi‐Wizsy, Silke Patz, Daniel T. Simon, Rainer Schindl

Advanced Materials Technologies· Volume 6· Issue 5
Publisher page
Source abstract

Abstract

In article number 2001302, Silke Patz, Daniel T. Simon, Rainer Schindl, and co-workers engineer an electronically-driven ion pump for the targeted delivery of the charged chemotherapeutic gemcitabine to brain cancer cells. By delivering drug ions over a cation exchange membrane at currents in the nanoampere range, brain cancer cell death and microtumor disintegration is triggered. This local gemcitabine treatment offers a therapeutical window, in contrast to standard treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Fuel Cells and Related Materials · Microfluidic and Capillary Electrophoresis Applications · Nanopore and Nanochannel Transport Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Gottfried Schatz Research Center – Biophysics Medical University of Graz Graz 8010 Austria

Laboratory of Organic Electronics Department of Science and Technology Linköping University Norrköping 60174 Sweden

Department of Neurosurgery Medical University of Graz Graz 8010 Austria

Diagnostic and Research Institute of Pathology Medical University of Graz Graz 8010 Austria

Institute of Chemical Technologies and Analytics Technische Universität Wien Vienna 1060 Austria

Division of Biomedical Research Medical University of Graz Graz 8036 Austria

Otto Loewi Research Center – Immunology and Pathophysiology Medical University of Graz Graz 8010 Austria

References

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