Microfluidic Systems: A 3D Biohybrid Real‐Scale Model of the Brain Cancer Microenvironment for Advanced In Vitro Testing (Adv. Mater. Technol. 10/2020)

In article number 2000540, Omar Tricinci, Daniele De Pasquale, Attilio Marino, Gianni Ciofani, and co-workers present a real-scale 3D-printed biohybrid microfluidic device that can mimic the glioblastoma microenvironment at the level of the blood–brain barrier, with both luminal and parenchyma compartments. It allows the triple co-culture of endothelial cells, astrocytes, and magnetically-driven spheroids of U87 glioblastoma cells. The device demonstrates to be successfully exploitable as a realistic in vitro model for high-throughput drug screening.