DataVXAdvanced Materials TechnologiesPaper
journal article·2020-10Open access

A One‐Step Biofunctionalization Strategy of Electrospun Scaffolds Enables Spatially Selective Presentation of Biological Cues

Paul Wieringa, Andre Girao, Maqsood Ahmed, Roman TruckenmÜller, Alexander Welle, Silvestro Micera, Richard van Wezel, Lorenzo Moroni

Advanced Materials Technologies· Volume 5· Issue 10
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Source abstract

Abstract

Abstract To recapitulate the heterogeneous complexity of tissues in the human body with synthetic mimics of the extracellular matrix (ECM), it is important to develop methods that can easily allow the selective functionalization of defined spatial domains. Here, a facile method is introduced to functionalize microfibrillar meshes with different reactive groups able to bind biological moieties in a one‐step reaction. The resulting scaffolds prove to selectively support a differential neurite growth after being seeded with dorsal root ganglia. Considering the general principles behind the method developed, this is a promising strategy to realize enhanced biomimicry of native ECM for different regenerative medicine applications.
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Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Tissue Regeneration MIRA Institute for Biomedical Technology and Technical Medicine University of Twente Enschede 7500AE The Netherlands

Department of Biomedical Signals and Systems MIRA Institute for Biomedical Technology and Technical Medicine Twente University Enschede 7500AE The Netherlands

BioRobotics Institute—Scuola Superiore Sant’Anna Pisa 56127 Italy

Istituto Italiano di Tecnologia Center for Micro‐BioRobotics @SSSA Viale Rinaldo Piaggio 34, Pontedera Pisa 56025 Italy

Department of Complex Tissue Regeneration MERLN Institute for Technology‐Inspired Regenerative Medicine Maastricht University Maastricht 6200 MD The Netherlands

Institute of Functional Interfaces (IFG) and Karlsruhe Nano Micro Facility (KNMF) Karlsruhe Institute of Technology (KIT) Eggenstein‐Leopoldshafen Karlsruhe 76344 Germany

Translational Neural Engineering Laboratory Center for Neuroprosthetics and Institute of Bioengineering School of Engineering Ecole Polytechnique Federale de Lausanne Lausanne 1015 Switzerland

Biophysics Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen 6525 AJ The Netherlands

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