Wearable Flexible Cold Atmospheric Plasma Devices: Key Technologies and Medical Application Prospects

ABSTRACT Cold atmospheric plasma (CAP) has garnered significant attention for its remarkable biomedical effects. With advances in flexible electronics and materials engineering, the integration of wearable design concepts into CAP systems has emerged as a promising direction to enable continuous, personalized, and user‐friendly medical treatment. This review comprehensively summarizes recent progress in flexible wearable CAP devices, which primarily rely on flexible dielectric barrier discharge (FXDBD) configurations implemented as patches or fabrics. The article systematically examines material selection spanning dielectrics, conductive electrodes, and functional substrates, as well as advanced manufacturing processes such as flexible printed circuit (FPC). Furthermore, it discusses power supply design and control strategies tailored for portable operation and safety compliance. Despite these advancements, current systems still face challenges in power autonomy, real‐time sensing, and adaptive control. Future development should focus on integrating intelligent feedback mechanisms, multimodal sensors, and artificial intelligence to enable responsive and personalized plasma therapy. It also addresses critical biosafety aspects, including UV exposure, electrical currents, and reactive species concentrations. By offering a thorough analysis of device architectures, material options, fabrication techniques, and emerging applications, this work aims to provide valuable insights to guide future research in developing next‐generation wearable CAP systems for precision medicine and personalized healthcare.