DataVXAdvanced Materials TechnologiesPaper
journal article·2024-11Open access

Highly Biocompatible Graphite Electrodes by Using Interface‐Stable Coating and the Application to Hemodialysis

Xinkai Xu, Yi Xu, Haitao Guo, Zanxin Zhou, Wenjie Hu, Leilei Wang, Shuang Li, Shugang Wang, Xu Zheng, Qi Gu, Yuan Xia, Jingqiang Cui, Guosheng Wang, Yewang Su

Advanced Materials Technologies· Volume 9· Issue 22
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Source abstract

Abstract

Abstract In the treatment of kidney diseases such as chronic kidney disease (CKD) and acute tubular necrosis (ATN), prolonged contact between conductivity sensors and patients' bodily fluids is required, necessitating high biocompatibility for the electrodes. However, the widely used graphite electrodes exhibit limited biocompatibility, showing a cell survival rate of only 88% under indirect contact conditions, and <56% under direct contact conditions. Here, the surface detachment of graphite electrodes in liquid environments leading to cell death upon contact is observed and a solution is proposed to enhance biocompatibility and ensure conductivity, by forming a layer of interface‐stable coating (ISC) as a conductive isolation membrane on their surface. For applications with contact requirements, graphite‐like carbon (GLC) coated graphite electrodes are investigated and developed, resulting in an exceptional cell survival rate exceeding 96% under indirect contact conditions, and a relatively high survival rate exceeding 91% under direct contact conditions, both accompanied by significant proliferation. GLC‐coated graphite electrodes are successfully to monitor the dialysate conductivity in a hemodialysis machine and achieve stable monitoring with temperature compensation. The results demonstrate ISC graphite electrodes' potential in biomedical fluid monitoring, with the developed process applicable to other fields.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Electrochemical sensors and biosensors · Advanced Sensor and Energy Harvesting Materials · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

School of Engineering Science University of Chinese Academy of Sciences Beijing 100049 China

Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Chaoyang Beijing 100101 China

Henan Key Laboratory of Medical Polymer Materials Technology and Application Tuoren Medical Device Research & Development Institute Co. Ltd. Tuoren Health Technology Industrial Park Changyuan Henan 453000 China

State Key Laboratory of Nonlinear Mechanics Beijing Key Laboratory of Engineered Construction and Mechanobiology Institute of Mechanics Chinese Academy of Science Beijing 100190 China

Beijing Institute for Stem Cell and Regenerative Medicine Chaoyang Beijing 100101 China

University of Chinese Academy of Sciences Huairou Beijing 101449 China

Beijing Key Laboratory of Engineered Construction and Mechanobiology Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

Funding

National Natural Science Foundation of China · Key Research Program of Frontier Science, Chinese Academy of Sciences

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