DataVXAdvanced Materials TechnologiesPaper
journal article·2024-06Open access

Double‐Sided, Thin‐Film Microelectrode Array with Hemispheric Electrodes for Subretinal Stimulation

Namju Kim, Yeji Hong, Seongkwang Cha, Yoo Na Kang, Hee Won Seo, Hyunmin Moon, Jungryul Ahn, Aseer Intisar, Minseok S. Kim, Seong‐Woo Kim, Yong Sook Goo, Sohee Kim

Advanced Materials Technologies· Volume 9· Issue 11
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Source abstract

Abstract

Abstract Components in neural implants, such as the electrode array and stimulator circuit, are often fabricated discretely. This modular fabrication scheme offers flexibility during development but poses difficulties during assembly, as components must be compactly integrated for implantation. It is particularly difficult in cases where the electrode array is required to have a high number of channels, such as in retinal prostheses. This paper presents the development of a parylene C‐based, double‐sided microelectrode array with 294 hemispheric electrodes for subretinal stimulation. The bonding pads on the bottom side of the double‐sided array are connected with electrodes through vias, eliminating the interconnection lines. The array can be integrated with a stimulator circuit through pad‐to‐pad bonding, resulting in a compact implant. The hemispheric electrodes are fabricated using thermally reflowed photoresist infillings, through which the height and width of the hemispheres can be easily controlled. The long‐term stability and biocompatibility of the materials and methods used to fabricate and package the electrodes are demonstrated in in vitro and in vivo environments over months. Finally, subretinal stimulation by the developed electrodes is successfully demonstrated using in vitro retinal patches from mice and monkeys.
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Research context

Biomaterials

OpenAlex topics: Neuroscience and Neural Engineering · Advanced Memory and Neural Computing · EEG and Brain-Computer Interfaces

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science of Technology Daegu 42988 Republic of Korea

Department of Physiology Korea University College of Medicine Seoul 02841 Republic of Korea

Neuroscience Research Institute Korea University College of Medicine Seoul 02841 Republic of Korea

Department of Medical Device Korea Institute of Machinery and Materials Daegu 42994 Republic of Korea

Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Biomedical Engineering Sungkyunkwan University Suwon 16419 Republic of Korea

Department of New Biology Daegu Gyeongbuk Institute of Science of Technology Daegu 42988 Republic of Korea

Department of Ophthalmology Korea University College of Medicine Seoul 02841 Republic of Korea

Department of Physiology Chungbuk National University School of Medicine Cheongju 28644 Republic of Korea

Department of Electrical and Computer Engineering University of California San Diego La Jolla CA 92093 USA

Funding

National Research Foundation of Korea · Daegu Gyeongbuk Institute of Science and Technology · Ministry of Science and ICT, South Korea

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