journal article·2022-05Open access

Transient Neurovascular Interface for Minimally Invasive Neural Recording and Stimulation

Adele Fanelli, Laura Ferlauto, Elodie Geneviève Zollinger, Olivier Brina, Phillippe Reymond, Paolo Machi, Diego Ghezzi

Advanced Materials Technologies· Volume 7· Issue 5

Abstract

Adv. Mater. Technol. 2022, 2, 2100176 DOI: 10.1002/admt.202100176 Figure 2i in the original manuscript contained an error in the right y-axis. The error was due to an incorrect conversion while calculating the charge injection capacity. The unit originally reported was mC cm−2 instead of µC cm−2. The findings and conclusions presented in the original article are not affected. An updated version of Figure 2 is given below. Accordingly, a correction was made in the text as follows: “The average (± s.d.) maximum injectable current (always limited by the Emc) was found to be 5.2 ± 4.8 mA (n = 15 electrodes from N = 4 devices) and the respective CIC was 263.6 ± 247.5 µC cm−2 (Figure 2i). Currents used in metallic stent-electrode arrays fall within the range sustainable by the polymeric electrode presented in this article.[6]” Also, the following sentences that were added to justify an unusual CIC higher than the CSC should be removed: “It must be noted though that the CSC is usually an overestimation of the charge transfer potential of the electrodes: in fact when stimulating in vivo, at high frequencies and short pulses, only the superficial layers of the bulk PEDOT:PSS film will be active.[8] Thus, the CIC is expected to be lower than the CSC (typically CIC is 5–20% of the CSC for metals and oxides).[29] In our measurements, PEDOT:PSS electrodes reported a CIC higher than the total CSC with high variability among electrodes. A similar trend has been reported already in literature for PEDOT-coated PtIr electrodes.[38] A factor contributing to the high CIC is the positive open circuit potential reached by the electrodes after a prolonged stimulation at low current pulses to reach stabilization at the electrode-electrolyte interface. This open circuit potential was positive for all electrodes (≈0.25 V for most electrodes with a few exceptions at 0.15 V), leading most electrodes to a positive Emc value for injected currents below 1500 µA.” The authors apologize for this mistake.
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Research context

OpenAlex topics: Neuroscience and Neural Engineering · EEG and Brain-Computer Interfaces · Advanced Memory and Neural Computing

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