DataVXAdvanced Materials TechnologiesPaper
journal article·2023-12Open access

Single‐Cell Impedance Tomography Using Rolled‐Up Microtubular Sensors

Sonja M. Weiz, Pallavi Jha, Kyounghun Lee, Raffael Herzer, Oliver G. Schmidt, Mariana Medina‐Sánchez

Advanced Materials Technologies· Volume 8· Issue 23
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Source abstract

Abstract

Abstract Single‐cell analysis techniques provide the opportunity to study the cellular heterogeneity that occurs between cells of the same tissue. These methods should ideally be non‐destructive and label‐free to allow long‐term measurements that do not impede with healthy cellular functions. To that end, a miniaturized electrical impedance tomography (µEIT) system is fabricated via rolled‐up nanotechnology to study the electrical properties of individual cells. The tube contains an array of 12 electrodes on its interior wall, and its diameter of ca. 30 µm is tuned to fit the size of a cell. First proof‐of‐concept measurements are carried out with silica and half‐metal coated microparticle phantoms. Additionally, the death of a single HeLa cell is monitored with the µEIT device over time. In the future, the system can be applied to study, e.g. the efficiency of drugs or the biocompatibility of materials on a single‐cell level.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Microfluidic and Bio-sensing Technologies · Electrical and Bioimpedance Tomography · Microfluidic and Capillary Electrophoresis Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Micro‐ and NanoBiomedical Engineering Group (MNBE) Institute for Emerging Electronic Technologies (IET) Leibniz Institute for Solid State and Materials Research (Leibniz IFW Dresden) Helmholtzstraße 20 01069 Dresden Germany

Department of Computational Science & Engineering Yonsei University Seoul 120–749 South Korea

Leibniz IFW Dresden Helmholtzstraße 20 01069 Dresden Germany

Research Center for Materials Architectures and Integration of Nanomembranes (MAIN) Chemnitz University of Technology Rosenbergstraße 6 09126 Chemnitz Germany

Chair of Micro‐ and NanoSystems Center for Molecular Bioengineering (B CUBE), and Dresden University of Technology (TU Dresden) 01062 Dresden Germany

Funding

Deutsche Forschungsgemeinschaft · HORIZON EUROPE European Research Council

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