Osseointegration Assessment of Multi‐Material Ti6Al4V‐β TCP Implants: An Experimental Study in Rats
Source abstract
Abstract
Abstract In the present study, mono‐ and multi‐material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure‐assisted sintering technique is employed to impregnate beta‐tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone‐implant fixation and osseointegration are assessed, by performing push‐out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push‐out forces are higher for the textured and multi‐material solution, when compared to non‐textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi‐material implant displayed higher fracture energy when compared to non‐textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi‐material solutions are highly effective to promote bone regeneration and enhance bone‐implant fixation for further application in orthopedic implants.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for MicroElectroMechanical Systems (CMEMS‐UMinho) University of Minho Campus de Azurém Guimarães 4800‐058 Portugal
Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Campus de Gualtar Braga 4710‐057 Portugal
ICVS/3B's – PT Government Associate Laboratory Braga/Guimarães 4710‐057 Portugal
Center for Innovation and Research in Oral Sciences (CIROS) Faculty of Medicine University of Coimbra FMUC Coimbra 3000‐075 Portugal
CICECO Aveiro Institute of Materials Department of Materials and Ceramic Engineering University of Aveiro Aveiro 3810‐193 Portugal
Funding
Fundação para a Ciência e a Tecnologia
References (50)
Show source-provided references
1. 10.1016/j.promfg.2017.09.10210.1016/j.promfg.2017.09.102 ↗
2. Holzwarth U. · 2012
3. 10.1016/j.msec.2016.01.03410.1016/j.msec.2016.01.034 ↗
4. 10.1016/j.biomaterials.2003.11.00210.1016/j.biomaterials.2003.11.002 ↗
5. 10.1016/j.mtla.2019.10026610.1016/j.mtla.2019.100266 ↗
6. 10.1016/j.msec.2019.01.01610.1016/j.msec.2019.01.016 ↗
7. 10.1016/j.triboint.2018.08.01210.1016/j.triboint.2018.08.012 ↗
8. 10.1007/s00170-013-5277-210.1007/s00170-013-5277-2 ↗
9. 10.1016/j.actbio.2019.05.04510.1016/j.actbio.2019.05.045 ↗
10. 10.1002/jbm.b.3396410.1002/jbm.b.33964 ↗
11. 10.1016/j.msec.2019.10990110.1016/j.msec.2019.109901 ↗
12. 10.1002/jbm.a.3027710.1002/jbm.a.30277 ↗
13. 10.1016/j.apsusc.2019.04.18710.1016/j.apsusc.2019.04.187 ↗
14. 10.1016/j.actbio.2018.11.01810.1016/j.actbio.2018.11.018 ↗
15. 10.1039/D0TB01379J10.1039/D0TB01379J ↗
16. 10.1016/j.jot.2017.05.00210.1016/j.jot.2017.05.002 ↗
17. 10.1002/jor.2334010.1002/jor.23340 ↗
18. 10.1007/s10439-016-1673-810.1007/s10439-016-1673-8 ↗
19. 10.1155/2014/46153410.1155/2014/461534 ↗
20. 10.1016/j.actbio.2014.10.01710.1016/j.actbio.2014.10.017 ↗
21. 10.1016/j.phpro.2011.03.13010.1016/j.phpro.2011.03.130 ↗
22. 10.1016/j.apsusc.2007.02.16810.1016/j.apsusc.2007.02.168 ↗
23. 10.1016/S0142-9612(96)00185-810.1016/S0142-9612(96)00185-8 ↗
24. 10.1016/j.apsusc.2018.02.11910.1016/j.apsusc.2018.02.119 ↗
25. 10.1016/j.jmbbm.2019.04.05210.1016/j.jmbbm.2019.04.052 ↗
26. 10.1021/acsami.5b1058910.1021/acsami.5b10589 ↗
27. 10.1002/jbm.b.3181410.1002/jbm.b.31814 ↗
28. Palmquist A. · J. Biomed. Mater. Res., Part A · 2010 · 92 · 147610.1002/jbm.a.32439 ↗
29. 10.1016/j.nano.2010.10.00610.1016/j.nano.2010.10.006 ↗
30. 10.1371/journal.pone.015750410.1371/journal.pone.0157504 ↗
31. 10.1016/S0142-9612(03)00377-610.1016/S0142-9612(03)00377-6 ↗
32. 10.1016/j.biomaterials.2010.09.01110.1016/j.biomaterials.2010.09.011 ↗
33. 10.1016/j.jmbbm.2018.08.04910.1016/j.jmbbm.2018.08.049 ↗
34. 10.1016/j.jmbbm.2019.02.02810.1016/j.jmbbm.2019.02.028 ↗
35. 10.1016/j.matlet.2016.04.07410.1016/j.matlet.2016.04.074 ↗
36. 10.1177/00221554030510031210.1177/002215540305100312 ↗
37. 10.4103/0019-5413.7712910.4103/0019-5413.77129 ↗
38. 10.1177/030098581559312410.1177/0300985815593124 ↗
39. 10.1016/j.nano.2016.08.00310.1016/j.nano.2016.08.003 ↗
40. 10.1016/j.biomaterials.2004.09.03910.1016/j.biomaterials.2004.09.039 ↗
41. 10.1016/j.jmbbm.2011.05.03710.1016/j.jmbbm.2011.05.037 ↗
42. 10.1016/j.msec.2019.11040610.1016/j.msec.2019.110406 ↗
43. 10.1016/j.actbio.2010.08.02010.1016/j.actbio.2010.08.020 ↗
44. 10.1016/j.jmbbm.2015.08.00410.1016/j.jmbbm.2015.08.004 ↗
45. 10.1016/j.jmbbm.2018.04.01010.1016/j.jmbbm.2018.04.010 ↗
46. 10.1016/j.matdes.2018.04.04910.1016/j.matdes.2018.04.049 ↗
47. 10.1016/j.micron.2005.07.00810.1016/j.micron.2005.07.008 ↗
48. 10.1016/j.ceramint.2015.08.00410.1016/j.ceramint.2015.08.004 ↗
49. 10.1016/j.msec.2014.06.01510.1016/j.msec.2014.06.015 ↗
50. 10.1016/j.jmbbm.2010.08.00410.1016/j.jmbbm.2010.08.004 ↗