DataVXAdvanced Materials TechnologiesPaper
journal article·2021-05

On the Improvement of Alveolar‐Like Microfluidic Devices for Efficient Blood Oxygenation

Magdalena Malankowska, Ismael Pellejero, Ignacio Julian, Hoon Suk Rho, Pedro Pinczowski, Roald M. Tiggelaar, Han Gardeniers, Reyes Mallada, Maria Pilar Pina

Advanced Materials Technologies· Volume 6· Issue 5
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Source abstract

Abstract

Abstract In this work, alveolar‐like microfluidic devices are studied with a horizontal membrane arrangement that demonstrate a great potential as small‐scale blood oxygenator. The design criteria for the fabricated devices are to maximize the oxygen saturation level and minimize liquid chamber volume while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. The liquid chamber architecture is iteratively modified upon analysis of the fluid dynamics by computer modeling. Accordingly, two alveolar type architectures are fabricated, Alveolar Design 1 (AD1) and Alveolar Design 2 (AD2), and evaluated for oxygenation of sheep blood. The attained O2 transfer rate at 1 mL min−1 of blood flow rate for both devices is rather similar: 123 and 127 mL min−1 m−2 for AD1 and AD2 microfluidic devices, respectively. Among the studied, AD2 type geometry would lead to the lowest pressure drop and shear stress value upon implementation in a scaled microfluidic artificial lung (μAL) to satisfy oxygenation requirements of a 2.0 kg neonate.
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Research context

OpenAlex topics: Mechanical Circulatory Support Devices · Fuel Cells and Related Materials · Transplantation: Methods and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Instituto de Nanociencia y Materiales de Aragón (INMA) Universidad de Zaragoza‐CSIC Zaragoza 50009 Spain

Departamento de Ingeniería Química y Tecnología del Medio Ambiente Universidad de Zaragoza Zaragoza 50009 Spain

Mesoscale Chemical Systems MESA+ Institute University of Twente P.O. Box 217 Enschede 7500 AE The Netherlands

Institute for Advanced Materials and Mathematics (INAMAT2) Public University of Navarra Edif. Jerónimo de Ayanz Campus Arrosadia, s/n Pamplona‐Iruña 31006 Spain

Department of Instructive Biomaterials Engineering MERLN Institute for Technology‐Inspired Regenerative Medicine Maastricht University Universiteitssingel 40 Maastricht 6229 ER The Netherlands

Veterinary School of Zaragoza C/Miguel Servet 177 Zaragoza 50013 Spain

MESA+ NanoLab cleanroom MESA+ Institute University of Twente P.O. Box 217 Enschede 11 7500 AE The Netherlands

Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER‐BBN Madrid 28029 Spain

Funding

Education, Audiovisual and Culture Executive Agency

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