DataVXAdvanced Materials TechnologiesPaper
journal article·2021-08Open access

A Microneedles Balloon Catheter for Endovascular Drug Delivery

Khalil Moussi, Ali A. Haneef, Rawiah A. Alsiary, Elhadj M. Diallo, Marijn Antoine Boone, Huda Abu‐Araki, Osman O. Al‐Radi, Jurgen Kosel

Advanced Materials Technologies· Volume 6· Issue 8
Publisher pageOpen full text
Source abstract

Abstract

Abstract Disorders of the inner parts of blood vessels have been significant triggers of cardiovascular diseases (CVDs). Different interventional methods have been employed, from complex surgeries to balloon angioplasty techniques to open the narrowed blood vessels. However, CVDs continue to be the lead cause of death in the world. Delivering a therapeutic agent directly to the inner wall of affected blood vessels can be a transformative step toward a better treatment option. To open the door for such an approach, a catheter delivery system is developed based on a conventional balloon catheter where a fluidic channel and microneedles (MNs) are integrated on top of it. This enables precise and localized delivery of therapeutics directly into vessel walls. Customizable MNs are fabricated using a high‐resolution 3D printing technique where MN's height ranges from 100 to 350 µm. The MNs penetration into a synthetic vascular model is investigated with a computerized tomography scan. Ex vivo tests on rabbit aorta confirm the MN‐upgraded balloon catheter's performance on real tissue. Delivery of fluorescent dye is accomplished by injecting it through the fluidic channel and MNs into the aortic tissue. The dye is observed at up to 180 µm of depth, confirming site‐specific endovascular delivery.
Source: crossref · Quality: baseline

Research context

Materials processing

OpenAlex topics: Coronary Interventions and Diagnostics · Optical Coherence Tomography Applications · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE) King Abdullah University of Science and Technology (KAUST) Thuwal 23955 Saudi Arabia

King Faisal Cardiac Center (KFCC) Jeddah 22384 Saudi Arabia

King Abdullah International Medical Research Center (KAIMRC) Jeddah 22384 Saudi Arabia

King Saud bin Abdulaziz University for Health Sciences (KSAU‐HS) Jeddah Saudi Arabia

Ali I. Al‐Naimi Petroleum Engineering Research Center (ANPERC) King Abdullah University of Science and Technology (KAUST) Thuwal 23955 Saudi Arabia

TESCAN XRE Bollebergen Ghent 9052 Belgium

Laboratory Animals Unit King Fahd Medical Research Center King Abdulaziz University Jeddah 22252 Saudi Arabia

Cardiac Surgery Division Department of Surgery King Abdulaziz University Jeddah 21589 Saudi Arabia

Department of Cardiothoracic Surgery King Faisal Specialist Hospital and Research Centre Jeddah 23431 Saudi Arabia

Sensor Systems Division (SeS) Silicon Austria Labs (SAL) Villach 9524 Austria

Funding

King Abdullah University of Science and Technology

References (45)

Show source-provided references
1. Word Health Organization The top 10 causes of death https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death(accessed: December2020).
2. Causes of death by Hannah Ritchie and Max Roser https://ourworldindata.org/causes-of-death(accessed: December2020).
3. Mendis S. · 2011
4. 10.3389/fcvm.2014.0001510.3389/fcvm.2014.00015 ↗
5. 10.1016/0002-9149(84)90752-510.1016/0002-9149(84)90752-5 ↗
6. 10.1016/S0008-6363(96)00038-710.1016/S0008-6363(96)00038-7 ↗
7. 10.1161/CIRCINTERVENTIONS.110.96087210.1161/CIRCINTERVENTIONS.110.960872 ↗
8. 10.1056/NEJM19870319316120110.1056/NEJM198703193161201 ↗
9. 10.1056/NEJM19940825331080210.1056/NEJM199408253310802 ↗
10. 10.1002/ccd.2212810.1002/ccd.22128 ↗
11. 10.1056/NEJM19910103324010310.1056/NEJM199101033240103 ↗
12. 10.1136/heart.89.2.21810.1136/heart.89.2.218 ↗
13. 10.1056/NEJMoa06772210.1056/NEJMoa067722 ↗
14. 10.1016/j.jacc.2006.03.04210.1016/j.jacc.2006.03.042 ↗
15. 10.1136/bmj.f662510.1136/bmj.f6625 ↗
16. 10.3390/jpm804003310.3390/jpm8040033 ↗
17. 10.1016/j.jcin.2013.06.01510.1016/j.jcin.2013.06.015 ↗
18. 10.1038/nrcardio.2013.16510.1038/nrcardio.2013.165 ↗
19. 10.15420/usc.2019.4.110.15420/usc.2019.4.1 ↗
20. 10.1002/ccd.2145210.1002/ccd.21452 ↗
21. 10.1007/978-3-319-92600-110.1007/978-3-319-92600-1 ↗
22. 10.1016/j.jcin.2012.06.01210.1016/j.jcin.2012.06.012 ↗
23. 10.1161/01.ATV.17.12.336510.1161/01.ATV.17.12.3365 ↗
24. 10.1016/j.atherosclerosis.2018.03.03910.1016/j.atherosclerosis.2018.03.039 ↗
25. 10.1016/j.drudis.2016.05.01710.1016/j.drudis.2016.05.017 ↗
26. 10.1161/CIRCINTERVENTIONS.113.00019510.1161/CIRCINTERVENTIONS.113.000195 ↗
27. 10.1016/j.jvs.2013.10.05110.1016/j.jvs.2013.10.051 ↗
28. Peppas A. · J. Am. Coll. Cardiol. · 2017 · 70
29. Moussi K. · 2018
30. Moussi K. · 2019
31. Moussi K. · 2019
32. Moussi K. · 2020
33. Bukhamsin A. · 2020
34. 10.1002/adem.20190135810.1002/adem.201901358 ↗
35. 10.5923/j.ajbe.20120202.0110.5923/j.ajbe.20120202.01 ↗
36. 10.1016/j.jvir.2010.05.03010.1016/j.jvir.2010.05.030 ↗
37. 10.1109/JMEMS.2018.281999410.1109/JMEMS.2018.2819994 ↗
38. 10.1088/0967-3334/23/4/30410.1088/0967-3334/23/4/304 ↗
39. 10.1016/j.actbio.2010.06.00810.1016/j.actbio.2010.06.008 ↗
40. Wang Z. · J. Appl. Polym. Sci. · 2014 · 131
41. 10.1109/JMEMS.2007.90746110.1109/JMEMS.2007.907461 ↗
42. 10.1016/j.jconrel.2006.02.01710.1016/j.jconrel.2006.02.017 ↗
43. 10.1021/js980085q10.1021/js980085q ↗
44. 10.1109/JPROC.2003.82054210.1109/JPROC.2003.820542 ↗
45. 10.1016/j.jcmg.2015.02.00310.1016/j.jcmg.2015.02.003 ↗