Bioinspired Perfluorocarbon‐Based Oxygen Carriers with Concave Shape and Deformable Shell
Source abstract
Abstract
Abstract Human red blood cells (hRBCs) possess a unique biconcave structure with a highly deformable cell membrane and condensed cytosol hemoglobin for oxygen delivery. Inspired by hRBCs, novel deformable core‐shell particles are developed as perfluorocarbon‐based oxygen carriers (OCs), called “cDFCs” (concave‐shaped deformable PFC‐based OCs), using the Shirasu porous glass (SPG) membrane emulsification technique. cDFCs have a perfluorooctyl bromide core of high oxygen solubility and poly(lactide‐co‐caprolactone) shell, which is thin and highly deformable. They have an optical equivalent diameter of 7.9 ± 2.5 µm and a unique concave shape. Owing to their low Young's modulus (93 kPa) and their diameter and shape, they successfully pass through a 4.5‐µm‐gap silicon microchannel as a blood capillary model. Enhanced oxygen supply to multiple layered cells is demonstrated under hypoxic conditions, indicating their efficiency as OCs. cDFCs are new potential OCs in tissue engineering and blood substitution in the future.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Hemoglobin structure and function · Erythrocyte Function and Pathophysiology · Heme Oxygenase-1 and Carbon Monoxide
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113‐8656 Japan
Center for Disease Biology and Integrative Medicine The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113‐0033 Japan
Department of Chemical System Engineering The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113‐8656 Japan
Kurita Water Industries Ltd 4‐10‐1 Nakano Nakano‐ku Tokyo 164‐0001 Japan
Department of Chemical Engineering Kyushu University 744 Motooka Nishi‐ku Fukuoka 819‐0395 Japan
Funding
Ministry of Education, Culture, Sports, Science and Technology · Japan Society for the Promotion of Science
References (46)
Show source-provided references
1. 10.1021/cr970143c10.1021/cr970143c ↗
2. 10.1182/blood-2008-07-16116610.1182/blood-2008-07-161166 ↗
3. 10.1073/pnas.050424310210.1073/pnas.0504243102 ↗
4. 10.1103/PhysRevLett.103.18810110.1103/PhysRevLett.103.188101 ↗
5. 10.1111/j.1525-1594.2009.00944.x10.1111/j.1525-1594.2009.00944.x ↗
6. 10.1038/nrd130710.1038/nrd1307 ↗
7. 10.1016/j.cis.2018.08.00610.1016/j.cis.2018.08.006 ↗
8. 10.1126/science.849352910.1126/science.8493529 ↗
9. 10.1152/ajpheart.00787.200410.1152/ajpheart.00787.2004 ↗
10. 10.1016/j.biomaterials.2015.02.11710.1016/j.biomaterials.2015.02.117 ↗
11. 10.1002/pola.2193710.1002/pola.21937 ↗
12. 10.1038/ncomms978510.1038/ncomms9785 ↗
13. 10.1002/adma.20170142910.1002/adma.201701429 ↗
14. 10.1016/j.ijpharm.2014.05.01210.1016/j.ijpharm.2014.05.012 ↗
15. 10.1039/C8TB01844H10.1039/C8TB01844H ↗
16. 10.1021/acs.langmuir.9b0019410.1021/acs.langmuir.9b00194 ↗
17. 10.1038/nrd349910.1038/nrd3499 ↗
18. 10.1073/pnas.090712710610.1073/pnas.0907127106 ↗
19. 10.1021/bm300724210.1021/bm3007242 ↗
20. 10.1002/adma.20130287510.1002/adma.201302875 ↗
21. 10.3389/fphys.2018.0082910.3389/fphys.2018.00829 ↗
22. 10.1016/0142-9612(81)90060-010.1016/0142-9612(81)90060-0 ↗
23. 10.1016/j.progpolymsci.2012.05.00310.1016/j.progpolymsci.2012.05.003 ↗
24. 10.1002/1521-4095(20020304)14:5<386::AID-ADMA386>3.0.CO;2-I10.1002/1521-4095(20020304)14:5<386::AID-ADMA386>3.0.CO;2-I ↗
25. 10.1016/j.cis.2004.10.00210.1016/j.cis.2004.10.002 ↗
26. 10.1016/j.colsurfb.2015.01.01810.1016/j.colsurfb.2015.01.018 ↗
27. 10.1016/S0006-3495(73)85983-110.1016/S0006-3495(73)85983-1 ↗
28. 10.1007/s11746-997-0143-810.1007/s11746-997-0143-8 ↗
29. 10.1016/j.jbiosc.2017.02.01210.1016/j.jbiosc.2017.02.012 ↗
30. 10.1038/s41598-017-08255-910.1038/s41598-017-08255-9 ↗
31. 10.1111/trf.1612210.1111/trf.16122 ↗
32. 10.1073/pnas.101001310810.1073/pnas.1010013108 ↗
33. 10.1038/nature1416810.1038/nature14168 ↗
34. 10.1073/pnas.20261729910.1073/pnas.202617299 ↗
35. 10.1371/journal.pone.021544710.1371/journal.pone.0215447 ↗
36. 10.1016/j.jbbm.2005.11.00310.1016/j.jbbm.2005.11.003 ↗
37. 10.1073/pnas.180650111510.1073/pnas.1806501115 ↗
38. 10.1182/blood-2010-10-31280110.1182/blood-2010-10-312801 ↗
39. 10.1073/pnas.243396810010.1073/pnas.2433968100 ↗
40. 10.1016/j.jbiomech.2014.03.03810.1016/j.jbiomech.2014.03.038 ↗
41. 10.1016/0026-2862(92)90082-Z10.1016/0026-2862(92)90082-Z ↗
42. 10.1016/j.addr.2014.12.00310.1016/j.addr.2014.12.003 ↗
43. 10.1016/j.addr.2016.02.00710.1016/j.addr.2016.02.007 ↗
44. 10.1016/j.biomaterials.2017.11.03110.1016/j.biomaterials.2017.11.031 ↗
45. 10.1038/nnano.2007.7010.1038/nnano.2007.70 ↗
46. 10.1016/j.cis.2017.05.01110.1016/j.cis.2017.05.011 ↗