DataVXAdvanced Materials TechnologiesPaper
journal article·2020-05

Modular and Customized Fabrication of 3D Functional Microgels for Bottom‐Up Tissue Engineering and Drug Screening

Wenguang Yang, Shuxiang Cai, Yibao Chen, Wenfeng Liang, Youbin Lai, Haibo Yu, Yuechao Wang, Lianqing Liu

Advanced Materials Technologies· Volume 5· Issue 5
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Source abstract

Abstract

Abstract Customized generation of 3D functional building blocks is crucial for bottom‐up tissue engineering. Currently, high throughput production, high survival rates, and well‐controlled shapes are considered as three major challenges in fabricating microgels. Here, an optofluidic maskless lithography system that combines digital micromirror device based 3D printing and microfluidic technologies for fabricating 3D functional microgels, is presented. With this system, 3D microgels can be custom designed online and manufactured modularly in a microfluidic device. The fabrication process is based on shadowed light, highly flexible, and requires no physical masks. Furthermore, cells in microgels exhibit features that are more similar to the complex in vivo conditions, including morphology, proliferation, and drug resistance.
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Research context

BiomaterialsMaterials processing

OpenAlex topics: 3D Printing in Biomedical Research · Innovative Microfluidic and Catalytic Techniques Innovation · Additive Manufacturing and 3D Printing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Electromechanical and Automotive Engineering Yantai University Yantai 264005 China

School of Mechanical Engineering Shenyang Jianzhu University Shenyang 110016 China

College of Engineering Shenyang Agricultural University Shenyang 110016 China

State Key Laboratory of Robotics Shenyang Institute of Automation Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang 110016 P. R. China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Shandong Province

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