Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers (Adv. Mater. Interfaces 30/2024)

Protein Functionalization Modification of proteins is often required for their use as targeting agents. However, chemical over-modification can lead to the loss of their native structure and thus affect their functionality. Based on NHS ester chemistry, in this article 2400472 by Katharina Landfester and co-workers, a minimal protein modification strategy including detailed characterization is developed, keeping the secondary structure intact and allowing their further attachment to nanocarriers via click chemistry.