A Thioether‐Bridging Surface Modification of Polymeric Microspheres Offers Nonbiological Protein A‐Mimetic Affinity for IgG (Adv. Mater. Interfaces 23/2024)

Bridging Surface Modification Just like the kids spreading their nets in pairs, thioether-bridge-modified polymeric surfaces selectively capture immunoglobulin G (IgG). Furthermore, they exhibit buffer responsiveness and high-affinity binding to the IgG Fc region, acting as protein A ligands. The bridging surface modification approach and the improved understanding of protein interactions at bridged/non-bridged interfaces could be valuable in widespread bio-applications. More details can be found in the article 2301028 by Takanori Kishida.