DataVXAdvanced Materials InterfacesPaper
journal article·2023-10Open access

Microvasculature‐on‐a‐Post Chip That Recapitulates Prothrombotic Vascular Geometries and 3D Flow Disturbance (Adv. Mater. Interfaces 29/2023)

Yingqi Zhang, San‐Seint‐Seint Aye, Vivian Cheng, Arian Nasser, Tianbo Hong, Parham Vatankhah, Fengtao Jiang, Yunduo Charles Zhao, Laura Moldovan, Allan Sun, Alexander Dupuy, Yao Wang, Zhiyong Li, Timothy Ang, Freda Passam, Ken‐Tye Yong, Lining Arnold Ju

Advanced Materials Interfaces· Volume 10· Issue 29
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Source abstract

Abstract

Microvasculature-on-a-Post Chip In article 2300234, Ju and co-workers introduced a microvasculature-on-a-post chip to investigate atherosclerosis-related conditions. This innovative device replicates endothelium lining in pathological vascular anatomies by mimicking stenotic vascular geometries extracted from the human body. This device enables visualization of thrombotic pathogenesis within the endothelialized microfluidic post model. This approach sheds light on the intricate interplay between flow disturbance and thrombosis in diseased blood vessels.
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Research context

OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation · 3D Printing in Biomedical Research

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Affiliations

School of Biomedical Engineering Faculty of Engineering The University of Sydney Darlington NSW 2008 Australia

Charles Perkins Centre The University of Sydney Camperdown NSW 2006 Australia

Heart Research Institute Newtown NSW 2042 Australia

The University of Sydney Nano Institute (Sydney Nano) The University of Sydney Camperdown NSW 2006 Australia

Department of Haematology Royal Prince Alfred Hospital Camperdown NSW 2006 Australia

School of Mechanical Medical and Process Engineering Queensland University of Technology Brisbane 4000 Australia

Departments of Interventional Neuroradiology Neurology Royal Prince Alfred Hospital Camperdown NSW 2006 Australia

Central Clinical School Faculty Medicine and Health The University of Sydney Camperdown NSW 2006 Australia

References

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