DataVXAdvanced Materials InterfacesPaper
journal article·2023-07Open access

Single‐Step Primary Amine Synthesis on Proton Sensitive Nanofilms to Overcome Its Debye Length Limitations

Chia‐Ming Yang, Hui‐Ling Liu, Chih‐Ching Ho, Hsieh‐Fu Tsai, Nikhil Bhalla

Advanced Materials Interfaces· Volume 10· Issue 21
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Source abstract

Abstract

Abstract The debye length is a measure of the distance over which the electric field of a charged particle decays in an electrolyte solution. If the binding of the analyte to the surface of the transducer is too far away from the surface, the electric field to the analyte may decay over a distance greater than the debye length thereby reducing the sensitivity of the measurement. In this context, this study has developed a simple one‐step protein immobilization strategy to covalently attach proteins on the sensor surface. Our binding strategy, which uses hydrogen peroxide (H2O2) ensures that the analyte is attached as close as possible to the transducer surface. This study evaluates our findings by comparing our strategy with silane chemistry and elucidating the debye length effects with colorimetric assays and field effect devices. Additionally, as a case study, we also evaluated the performance of our methodology for the detection of glucose oxidation by a field effect device. Overall, the developed immobilization strategy avoids the effects of the debye length and improves the performance of the biosensor.
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Research context

Energy storageNanomaterials

OpenAlex topics: Analytical Chemistry and Sensors · Advanced biosensing and bioanalysis techniques · Electrochemical sensors and biosensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electronic Engineering Chang Gung University Taoyuan City 33302 Taiwan

Institute of Electro‐Optical Engineering Chang Gung University Taoyuan City 33302 Taiwan

Biosensor Group Biomedical Engineering Research Center Chang Gung University Taoyuan City 33302 Taiwan

Department of General Surgery Chang Gung Memorial Hospital at Linkou Taoyuan City 33302 Taiwan

Department of Neurosurgery Chang Gung Memorial Hospital at Linkou Taoyuan City 33302 Taiwan

Department of Biomedical Engineering Chang Gung University Taoyuan City 33302 Taiwan

Department of Neurosurgery Chang Gung Memorial Hospital Keelung Keelung City 204 Taiwan

Nanotechnology and Integrated Bioengineering Centre (NIBEC) School of Engineering Ulster University York Street, Belfast Northern Ireland BT15 1ED UK

Healthcare Technology Hub Ulster University York Street, Belfast Northern Ireland BT15 1ED UK

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