DataVXAdvanced Materials InterfacesPaper
journal article·2023-06Open access

Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype (Adv. Mater. Interfaces 18/2023)

Pouria Fattahi, Yin‐Ting Yeh, Tiankai Zhao, Mousa Younesi, Changjin Huang, Mauricio Terrones, Siyang Zheng, Justin L. Brown, Dan Dongeun Huh, Sulin Zhang, Peter J. Butler

Advanced Materials Interfaces· Volume 10· Issue 18
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Source abstract

Abstract

Mechanotargeting of Atherogenic Endothelium In article number 202300137, Pouria Fattahi, Sulin Zhang, Peter J. Butler, and colleagues provide direct evidence for cell mechanics-based targeting of nanoparticles (NPs) to atherogenic endothelium, a drug-delivery strategy termed, mechanotargeting. Microcontact-patterned adhesive islands induce endothelial cells to adopt prescribed morphologies that mimic shear flow-induced phenotypes in vivo, resulting in increases in NP uptake with decreases in cellular mechanical stress.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease · Nanoplatforms for cancer theranostics · Atherosclerosis and Cardiovascular Diseases

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Affiliations

Department of Biomedical Engineering Pennsylvania State University University Park PA 16802 USA

Department of Bioengineering University of Pennsylvania Philadelphia PA 19104 USA

Department of Physics Pennsylvania State University University Park PA 16802 USA

Department of Engineering Science and Mechanics Pennsylvania State University University Park PA 16802 USA

Department of Biomedical Engineering Carnegie Mellon University Pittsburgh PA 15213 USA

Department of Materials Science and Engineering Pennsylvania State University University Park PA 16802 USA

References

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