DataVXAdvanced Materials InterfacesPaper
journal article·2022-12Open access

Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7 (Adv. Mater. Interfaces 35/2022)

Shiyu Sun, Cen Cao, Yaru Guo, Yi Hou, Yanze Meng, Yuman Li, Feng Mei, Zhewen Hu, Yao Li, Yuting Niu, Yiming Chen, Lili Chen, Ying Huang, Xuliang Deng

Advanced Materials Interfaces· Volume 9· Issue 35
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Source abstract

Abstract

Sprouting Angiogenesis Deceleration Deceleration of sprouting angiogenesis after vessel reconstruction is crucial for controlled tissue repair. As reported by Shiyu Sun, Cen Cao, and colleagues in article number 2201719, in bone defect healing, osteogenic-differentiated bone marrow stem cells contribute to sprouting angiogenesis deceleration by paracrine excreting insulin-like growth factor-binding protein 7 (IGFBP7), which inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. This study suggests the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.
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Research context

OpenAlex topics: Mesenchymal stem cell research

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Affiliations

Beijing Laboratory of Biomedical Materials Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 China

Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

School of Stomatology Tongji Medical College Huazhong University of Science and Technology Wuhan 430040 China

Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022 China

College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

References

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