DataVXAdvanced Materials InterfacesPaper
journal article·2022-02Open access

Plastic Antibodies Mimicking the ACE2 Receptor for Selective Binding of SARS‐CoV‐2 Spike (Adv. Mater. Interfaces 5/2022)

Alex D. Batista, Soumya Rajpal, Benedikt Keitel, Sandra Dietl, Beatriz Fresco‐Cala, Mehmet Dinc, Rüdiger Groß, Harald Sobek, Jan Münch, Boris Mizaikoff

Advanced Materials Interfaces· Volume 9· Issue 5
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Source abstract

Abstract

Plastic Antibodies for Selective Binding of SARS-CoV-2 Spike In article number 2101925, Alex D. Batista, Beatriz Fresco-Cala, and co-workers design and synthesize the very first silane-based silica core/shell molecularly imprinted polymers using an epitope peptide from SARS-CoV-2 spike protein as a template, which can act as a synthetic angiotensin-converting enzyme 2 receptor (ACE2) and bind to SARS-CoV-2. The interactions between the epitope template and the organosilane monomers are predicted via molecular docking simulations.
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Research context

Polymers

OpenAlex topics: Surface Modification and Superhydrophobicity · Protein purification and stability · Nanomaterials and Printing Technologies

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Affiliations

Institute of Analytical and Bioanalytical Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm Germany

Institute of Chemistry Federal University of Uberlandia Av. Joao Naves de Ávila 2121 Uberlândia 38400‐902 Brazil

Department of Biochemical Engineering and Biotechnology Indian Institute of Technology Delhi Hauz Khas New Delhi 110 016 India

Hahn‐Schickard Sedanstraße 14 89077 Ulm Germany

Institute of Molecular Virology Ulm University Medical Center Meyerhofstr. 1 89081 Ulm Germany

Labor Dr. Merk & Kollegen GmbH Beim Braunland 1 88416 Ochsenhausen Germany

References

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