DataVXAdvanced Materials InterfacesPaper
journal article·2021-12Open access

Biophysical Considerations in the Rational Design and Cellular Targeting of Flexible Polymeric Nanoparticles (Adv. Mater. Interfaces 23/2021)

Samaneh Farokhirad, Sreeja Kutti Kandy, Andrew Tsourkas, Portonovo S. Ayyaswamy, David M. Eckmann, Ravi Radhakrishnan

Advanced Materials Interfaces· Volume 8· Issue 23
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Source abstract

Abstract

Flexible Polymeric Nanoparticles In article number 2101290, Samaneh Farokhirad, Ravi Radhakrishnan, and co-workers explore the biophysical principles behind the effect of shape, chemistry, and flexibility of nanoparticles on multivalent ligand–receptor-mediated avidity and cellular uptake. The findings help establish rational design principles that confer tension, membrane excess area, and cytoskeletal sensing properties to the nanoparticles, which can be exploited for cell-specific targeting in nanomedicine applications.
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Research context

PolymersNanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Advanced Nanomaterials in Catalysis · Cancer Research and Treatment

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Affiliations

Department of Mechanical Engineering New Jersey Institute of Technology Newark NJ 07114 USA

Department of Chemical and Biomolecular Engineering University of Pennsylvania Philadelphia PA 19104 USA

Department of Bioengineering University of Pennsylvania Philadelphia PA 19104 USA

Department of Mechanical Engineering and Applied Mechanics University of Pennsylvania Philadelphia PA 19104 USA

Department of Mechanical and Aerospace Engineering University of California Los Angeles CA 90095 USA

Department of Anesthesiology The Ohio State University Columbus OH 43210 USA

References

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