Biomaterials: Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy (Adv. Mater. Interfaces 19/2020)
Source abstract
Abstract
In article number 2000935, Yin-Jia Cheng, Xian-Zheng Zhang and co-workers successfully prepared a photosensitizer-peptide amphiphile conjugate, which displays specific cellular uptake by tumor cells, and directly delivers doxorubicin to nucleus and protoporphyrin IX to mitochondria. The nanosystem can significantly maximize the therapeutic effect against tumor cells with minimal off-target cytotoxicity, thus holding great potential for enhanced chemo-photodynamic tumor therapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Click Chemistry and Applications
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Affiliations
School of Chemistry and Materials Science South‐Central University for Nationalities Wuhan 430074 P. R. China
Key Laboratory of Biomedical Polymers of Ministry of Education, and Department of Chemistry Wuhan University Wuhan 430072 P. R. China
References
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