Spiked Nanostructures Disrupt Fungal Biofilm and Impart Increased Sensitivity to Antifungal Treatment (Adv. Mater. Interfaces 12/2022)
Source abstract
Abstract
Antimicrobial Surface with Sharp Protrusions In article number 2102353, Andrew Hayles, Krasimir Vasilev, and co-workers demonstrate that fungal pathogens experience severe cell wall stress and impeded hyphae formation when incubated on nanostructured antimicrobial surfaces. This results in disrupted biofilms which are markedly more sensitive to antifungal drugs at subclinical concentrations. Amphotericin B entirely eradicates C. albicans on the nanostructured surface while failing to clear cells on the smooth control.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Medical and Biological Ozone Research · 3D Printing in Biomedical Research · Laser Applications in Dentistry and Medicine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Academic Unit of STEM University of South Australia Mawson Lakes Adelaide South Australia 5095 Australia
Adelaide Dental School University of Adelaide Adelaide South Australia 5005 Australia
Corin Australia Baulkham Hills New South Wales 2153 Australia
References
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