journal article·2016-10Open access

Cell Motility: Surface‐Grafted Nanogel Arrays Direct Cell Adhesion and Motility (Adv. Mater. Interfaces 20/2016)

Antonio Sechi, Joana M. G. Freitas, Patrick Wünnemann, Alexander Töpel, Rafaella T. Paschoalin, Sabrina Ullmann, Ricarda Schröder, Gülcan Aydin, Stephan Rütten, Alexander Böker, Martin Zenke, Andrij Pich

Advanced Materials Interfaces· Volume 3· Issue 20

Abstract

Antonio Sechi and co-workers describe the fabrication of highly functional and stimuli-responsive nanogel arrays grafted onto glass surfaces by a printing process using wrinkled PDMS templates in article 1600455. These nanogels influence size and dynamics of focal adhesions as well as cell motility forcing cells to move along highly directional trajectories. The modulation of nanogel topographical and mechanical properties by temperature or spacing serves as an effective tool for the regulation of cell motility.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications

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Affiliations

Institute of Biomedical Engineering Dept. of Cell Biology Uniklinik RWTH Aachen Pauwelsstrasse 30 D‐52074 Aachen Germany

DWI – Leibniz Institute for Interactive Materials e.V Forckenbeckstrasse 50 D‐52074 Aachen Germany

Electron Microscopy Facility Uniklinik RWTH Aachen Pauwelsstrasse 30 D‐52074 Aachen Germany

Lehrstuhl für Polymermaterialien und Polymertechnologien Universität Potsdam c/o Fraunhofer Institute for Applied Polymer Research Geiselbergstraße 69 D‐14476 Potsdam‐Golm Germany

References

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