Tuning of Surface Charge of Functionalized Poly(Carboxybetaine) Brushes Can Significantly Improve Label‐Free Biosensing in Complex Media (Adv. Mater. Interfaces 33/2022)

Poly(carboxybetaine) Functionalization Proper restoration of zwitterionic balance after functionalization of poly(carboxybetaine) brushes (pCB) is critical for pCB-biorecognition coatings with excellent antifouling properties. In article number 2201210, Ivana Víšová, Milan Houska, Hana Vaisocherová-Lísalová, and colleagues present a method using tailor-made mixtures of agents allowing tuning of the surface charge balance. This approach improves antifouling of functionalized pCBs by several orders of magnitude, which has a significant impact on label-free biosensing in complex media.