Development of a Protein Mimic with Peptide Ligands to Enhance Specific Sensing and Targeting by the Zwitterionic Surface Engineering of Poly(amido amine) Dendrimers
Source abstract
Abstract
A full layer of zwitterionic carboxybetaine-modified G5 PAMAM with extra targeting c(RGDyK) motifs shows excellent biocompatibility and about 100 times higher efficacy than free c(RGDyK) motifs while high selectivity of c(RGDyK) is preserved. This work provides a rational method to design protein-like molecules to obtain therapeutic function.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Dendrimers and Hyperbranched Polymers · RNA Interference and Gene Delivery · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical and Biological Engineering, State Key Laboratory of Chemical Engineering Zhejiang University Hangzhou 310027 China
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science Nanjing Normal University Nanjing 210046 China
Funding
National Nature Science Foundation of China · Ph.D. Programs Foundation of Ministry of Education of China · Zhejiang Provincial Natural Science Foundation of China
References (37)
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