A Flexible‐Substrate 5‐µm‐Diameter Needle Electrode: Minimizing Neuronal Death and Enabling Year‐Long Neural Recording
Source abstract
Abstract
Abstract Long‐term quantitative observations of the physiological state of the brain are essential technologies in various fields. In vivo electrophysiology with microelectrodes enables high spatiotemporal recordings of neuronal activities; however, tissue damage occurs due to electrode penetration, which limits the recording period. A neural recording technology is introduced that uses a 5‐µm‐diameter microneedle electrode device. The electrode implanted in the mouse cortex shows in vivo recording capabilities 1 day after implantation, which exceeds the year‐long duration. The electrode does not significantly increase neuronal death compare with tissue without electrode implantation. A noise‐reduced recording configuration is also demonstrated for the microneedle electrode, which enhances the recording performance for freely moving animals.
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Research context
OpenAlex topics: Neuroscience and Neural Engineering · EEG and Brain-Computer Interfaces · Advanced Memory and Neural Computing
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Electrical and Electronic Information Engineering Toyohashi University of Technology 1‐1 Hibarigaoka Tempaku‐cho Toyohashi 441‐8580 Japan
Institute for Research on Next‐generation Semiconductor and Sensing Science (IRES2) Toyohashi University of Technology 1‐1 Hibarigaoka Tempaku‐cho Toyohashi 441‐8580 Japan
Department of Applied Chemistry and Life Science Toyohashi University of Technology 1‐1 Hibarigaoka Tempaku‐cho Toyohashi 441‐8580 Japan
Department of Computer Science and Engineering Toyohashi University of Technology 1‐1 Hibarigaoka Tempaku‐cho Toyohashi 441‐8580 Japan
Funding
Takeda Science Foundation
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