DataVXACS NanoPaper
journal article·2018-12-26

Decoding the Information Contained in Fluorophore Radiation Patterns

Maia Brunstein, Adi Salomon, Martin Oheim

ACS Nano· Volume 12· Issue 12
Publisher page
Source abstract

Abstract

Dipole radiation patterns change when a fluorescent molecule comes close to the boundary between media of different refractive indices. Near-interface molecules emit mostly into the higher-index medium, predominantly around the critical angle. The radiation pattern encodes information about the emitter distance, orientation, and the refractive index of the embedding medium. Analyses of the supercritical angle fluorescence on pupil plane images can retrieve this information and have been applied both for refractometry with subcellular resolution and for the detection of metabolically active cancerous cells. In this issue of ACS Nano, Ferdman et al. employ this strategy in a label-free assay for detecting single bacteria, based on measuring the refractive-index change produced by bacterial growth in a fluorophore-coated microfluidic channel.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Biosensing Techniques and Applications · Microfluidic and Bio-sensing Technologies · Microfluidic and Capillary Electrophoresis Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CNRS, UMR 8118, Brain Physiology Laboratory, 45 rue des Saints Pères, Paris F-75006 France

Fédération de Recherche en Neurosciences FR3636, Faculté de Sciences Fondamentales et Biomédicales, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris F-75006, France

Chaire d’excellence Université Sorbonne Paris Cité, Paris F-75006 France

Department of Chemistry, Institute of Nanotechnology and Advanced Materials (BINA), Bar-Ilan University, Ramat-Gan 5290002, Israel

Joseph Meyerhof Invited Professor, Department of Biomolecular Sciences, Weizmann Institute for Science, Rehovot 7610001, Israel

Funding

Agence Nationale de la Recherche · Universit? Paris Descartes · CNRS · Universit? Sorbonne Paris Cit?

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