journal article·2024-08Open access

Phospholipid‐Modified Titanium Surface‐Loaded Apoptotic Extracellular Vesicles Promote Early Angiogenesis and Improve Implant Osseointegration Through Immune Regulation

Yicheng Chen, Xiaona Ning, Simin Zhu, He Xin, Xiaomin Ren, Pei Wang, Yu Zhang, Yufan Zhang, Yijing Chen, Yunpeng Li, Fuwei Liu, Feng Ding

Advanced Materials Interfaces· Volume 11· Issue 24

Abstract

Abstract Tissue‐engineered extraction products, such as apoptotic extracellular vesicles (ApoEVs), significantly promote tissue regeneration, endowing them with the potential to improve osseointegration. However, there is an urgent need to determine how to effectively load these materials onto a material surface to maximize their function. Considering that all such products have a phospholipid bilayer, a phospholipid‐modified implant coating is designed that can effectively load tissue‐engineered products with a phospholipid bilayer structure. ApoEVs are effectively loaded onto the surface and the osteogenic effect improved, achieving good osseointegration. In vitro experiments show that this material improves angiogenesis by promoting macrophage M1 polarization and NO secretion in the early stages. In vivo experiments show that after implantation, it effectively improve the peri‐implant vascularization of the implant, thereby improving the new bone formation ability and osseointegration. This study provides a universal solution for loading vesicular tissue‐engineered products onto an implant surface and validates its ability to improve bone fusion using ApoEVs as an example while exploring its mechanism.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Extracellular vesicles in disease · RNA Interference and Gene Delivery · MicroRNA in disease regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial Surgery School of Stomatology The Fourth Military Medical University Xi'an 710032 P. R. China

Department of Ophthalmology Tangdu Hospital Fourth Military Medical University Xi'an 710038 P. R. China

College of Life Sciences Northwest University Xi'an 710032 P. R. China

The 900th Hospital of Joint Logistic Support Force, PLA Fuzhou Fujian 350001 P. R. China

Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University 157 West 5th Road Xi'an Shaanxi 710004 P. R. China

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Clinical Research Center for Oral Diseases Department of Radiology School of Stomatology The Fourth Military Medical University Xi'an Shaanxi 710032 P. R. China

Department of Digital Dental Center The Affliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712046 P. R. China

The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai Shandong 264000 P. R. China

Funding

National Natural Science Foundation of China

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