Source abstract
Abstract
Abstract Visualization of dynamic interlinking networks which respond and adapt to the constantly changing environment would be highly beneficial in developing new composite materials and active/responsive materials. Here, optically and structurally stabilized plasmo‐bio interlinking networks (PBINs) free from photobleaching for high resolution, long term visualization are reported. Necessary for structural and optical stability, a new stability algorithm to comprehensively quantify stability and detect minute instability undetectable by traditional methods is introduced. Biocompatible plasmonic gold nanorods (Bio‐AuNRs) are synthesized for high resolution, long term imaging by utilizing bromide‐free alternatives to achieve CTA+ free. Systematic physical, chemical, and biological characterizations reveal the structural and optical stability of Bio‐AuNRs required for constructing PBIN. Lastly, with actin as a model of interlinking networks of the cytoskeleton, optically and structurally stable PBIN (100% CTA+ free, 97% crosslinking rate) in applications as active/responsive materials, are demonstrated.
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Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoparticles: synthesis and applications · Nanoparticle-Based Drug Delivery
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Affiliations
Department of Electrical and Computer Engineering University of Michigan Ann Arbor MI 48109 USA
Department of Chemistry Indiana University Bloomington IN 47405 USA
Department of Mechanical Engineering Center for Integrative Research in Critical Care University of Michigan Ann Arbor MI 48109 USA
Department of Electrical and Computer Engineering Department of Biomedical Engineering Biointerfaces Institute Macromolecular Science and Engineering University of Michigan Ann Arbor MI 48109 USA
Funding
Air Force Office of Scientific Research · National Science Foundation · University of Michigan
References (40)
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