Antibacterial Mesoporous Titania Films with Embedded Gentamicin and Surface Modified with Bone Morphogenetic Protein 2 to Promote Osseointegration in Bone Implants
Source abstract
Abstract
Abstract Novel approaches are needed to avoid bacterial infections following implant surgery. Here the use of mesoporous titania films (MTFs) for gentamicin loading and delivery and the surface functionalization of MFTs with human recombinant bone morphogenetic protein 2 (hrBMP‐2) are discussed. Gentamicin is incorporated into the MTF pores by immersion of the porous materials in gentamicin solution while hrBMP‐2 is adsorbed on top of the MTF. Contact angle and X‐ray photoelectron spectroscopy measurements are performed to prove gentamicin loading and hrBMP‐2 functionalization. An initial burst release of gentamicin takes place in physiological media followed by a prolonged release that lasts weeks. Such a release profile is highly appealing for bone implants where a high concentration of antibiotics is necessary during implant surgery while a lower antibiotic concentration is needed until tissue is regenerated. The MTFs loaded with gentamicin and functionalized with hrBMP‐2 are effective against Staphylococcus aureus colonization, and the presence of hrBMP‐2 enhances MC3T3‐E1 preosteoblastic cell attachment, proliferation, and differentiation.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Orthopedic Infections and Treatments · Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Soft Matter Nanotechnology Laboratory CIC biomaGUNE Paseo de Miramón 182 20014 Donostia‐San Sebastián Spain
NanoBioMedical Center Adam Mickiewicz University Umultowska 85 61–614 Poznan Poland
Research Center for Human Tissues & Organs Degeneration Shenzhen Institute of Advanced Technology Chinese Academy of Science Shenzhen Guangdong 518055 China
Gerencia Química—Centro Atómico Constituyentes Comisión Nacional de Energía Atómica CONICET Avenida General Paz 1499, B1650KNA San Martín Buenos Aires Argentina
Nanostructure Group ZIK HIKE University of Greifswald Fleischmannstraße 42–44 17489 Greifswald Germany
Ikerbasque Basque Foundation for Science 48013 Bilbao Spain
Donostia International Physics Center Paseo de Manuel Lardizabal 4 20018 Donostia‐San Sebastián Spain
Funding
Guangdong Science and Technology Department · Ministerio de Economía, Industria y Competitividad, Gobierno de España
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