DataVXAdvanced Materials InterfacesPaper
journal article·2020-11Open access

Amphiphilic Functionalized Oligomers: A Promising Strategy for the Postfabrication Functionalization of Liposomes

Christian Wölk, Hafiz Awais Nawaz, Iram Maqsood, Fabio Strati, Gerald Brezesinski, Gerd Hause, Michaela Schulz‐Siegmund, Michael C. Hacker

Advanced Materials Interfaces· Volume 7· Issue 22
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Source abstract

Abstract

Abstract Liposomes are promising drug carriers already used in clinical practice, but feasible methods for surface modifications are needed to enhance the application spectrum. This work describes the establishment of the first representative of amphiphilic functionalized oligomers as universal tool for the tuning of liposome characteristics based on a flexible building block strategy. The oligomer binds to liposomes composed of different lipids and modifies the surface characteristics. The charge of neutrally and even negatively charged liposomes is switched to a positive surface charge by grafting liposomes with the novel oligomer to create hybrid vesicles while integrity and structure of liposomes is not affected. The role of the alkyl chain anchors of the oligomer as driving force for formation of hybrid vesicles is demonstrated. The oligomer modification of liposomes is utilized to enhance the biological behavior of the vesicles demonstrated by an enhanced uptake in fibroblasts.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Lipid Membrane Structure and Behavior · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Pharmaceutical Technology Institute of Pharmacy Medical Faculty Leipzig University Eilenburger Straße 15a Leipzig 04317 Germany

Institute of Pharmacy Martin Luther University Halle‐Wittenberg Halle (Saale) 06120 Germany

Institute of Pharmaceutical Sciences (IPS) University of Veterinary and Animal Sciences (UVAS) Abdul Qadir Jillani Road Lahore 54000 Pakistan

Institute of Applied Dermatopharmacy Martin Luther University Halle‐Wittenberg Weinbergweg 23 Halle (Saale) 06120 Germany

Biocenter Martin Luther University Halle‐Wittenberg Weinbergweg 22 Halle 06120 Germany

Institute of Pharmaceutics and Biopharmaceutics Heinrich Heine University Düsseldorf Universitätsstraße 1 Düsseldorf 40225 Germany

Funding

Deutsche Forschungsgemeinschaft · Higher Education Commission, Pakistan · Deutscher Akademischer Austauschdienst

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