Conformal Electrodeposition of Antimicrobial Hydrogels Formed by Self‐Assembled Peptide Amphiphiles
Source abstract
Abstract
Abstract The colonization of biomedical surfaces by bacterial biofilms is concerning because these microorganisms display higher antimicrobial resistance in biofilms than in liquid cultures. Developing antimicrobial coatings that can be easily applied to medically‐relevant complex‐shaped objects, such as implants and surgical instruments, is an important and challenging research direction. This work reports the preparation of antibacterial surfaces via the electrodeposition of a conformal hydrogel of self‐assembling cationic peptide‐amphiphiles (PAs). Hydrogels of three PAs are electrodeposited: C16K2, C16K3, and C18K2, where Cn is an alkyl chain of n methylene groups and Km is an oligopeptide of m lysines. The processing variables (electrodeposition time, potential, pH, salt concentration, agitation) enable fine control of film thickness, demonstrating the flexibility of the method and allowing to unravel the mechanisms underlying electrodeposition. The electrochemically prepared hydrogels inhibit the growth of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa in agar plates, and prevent the formation of biofilms of Acinetobacter baumannii and P. aeruginosa and the formation of A. baumannii colonies in solid media. C16K2 and C16K3 hydrogels outperform the antimicrobial activity of those of C18K2 while maintaining good compatibility with human cells.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Antimicrobial Peptides and Activities · Polydiacetylene-based materials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Química Inorgánica Analítica y Química Física CONICET‐Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Instituto de Química de los Materiales Ambiente y Energía (INQUIMAE) Buenos Aires C1428EGA Argentina
Department of Pharmaceutical Sciences College of Pharmacy University of Nebraska Medical Center Omaha NE 68198‐6125 USA
Biopolymers Group Centro de Investigaciones en Bionanociencias (CIBION‐CONICET) Buenos Aires C1425FQD Argentina
Department of Biochemistry and Department of Food Science and Technology University of Nebraska‐Lincoln Lincoln NE 68588 USA
Faculty of Biological and Environmental Science Federal University of Grande Dourados Dourados MS 79804–970 Brazil
Department of Biochemistry Department of Food Science and Technology Department of Chemistry Nebraska Food for Health Center Center for Integrated Biomolecular Communication University of Nebraska‐Lincoln Lincoln NE 68588 USA
Funding
Agencia Nacional de Promoción Científica y Tecnológica · National Science Foundation
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